Study of polysaccharides of Foeniculum vulgare for use as a biologically active food supplement
https://doi.org/10.21323/2618-9771-2025-8-3-423-430
Abstract
The mineral composition of the phytomass of common fennel (Foeniculum vulgarе) growing in the mountainous regions of Uzbekistan has been studied. A high content of biogenic elements, including calcium, potassium, magnesium, phosphorus, sodium and iron has been established in this type of raw material. Water-soluble polysaccharides have been isolated from Foeniculum vulgare. The carbohydrate content in the purified polysaccharide samples was tested by the phenol-sulfuric acid method and amounted to 95.0–99.4%. The analysis of the monosaccharide composition showed that the neutral polysaccharide composition is represented by monosaccharides in the following composition: glucose — 54.1±2.5%, galactose — 21.5±0.95%, mannose — 12.9±0.61%. The composition of the acidic polysaccharide is represented by the following monosaccharides: glucose — 42.6±2.11%, galactose — 22.9±1.13%, mannose — 14.5±0.68%. The results of IR spectroscopic studies showed that the isolated polysaccharides consist mainly of α-linked pyranose units. The study of acute toxicity of polysaccharides showed that they belong to class V of practically non-toxic compounds. LD50 when administered orally to mice was more than 10000 mg/kg. The therapeutic action of Foeniculum vulgare polysaccharides had a positive effect on the lipid background of rabbits with atherosclerosis caused by cholesterol, as well as a hypercoagulation effect in rabbits with atherosclerosis both by the extrinsic pathway of blood coagulation and by the intrinsic one due to thrombin inhibition. The revealed biological activity of polysaccharides of Foeniculum vulgare will serve to develop a biologically active supplement based on them.
Keywords
Foeniculum vulgare,
polysaccharides,
ion-exchange chromatography,
gel filtration,
monosaccharide composition,
IR spectroscopy
Supporting agencies: This work was funded by the budget of the acad. A. Sadikov Institute of Bioorganic Chemistry of Uzbekistan Academy of Sciences.
About the Authors
A. V. Filatova
Institute of Bioorganic Chemistry
Uzbekistan
Uzbekistan
Albina V. Filatova, Leading Researcher, Doctor of Technical Science
Mirzo Ulugbek str., 83, Tashkent, 100125
L. B. Azimova
Institute of Bioorganic Chemistry
Uzbekistan
Uzbekistan
Luiza B. Azimova, Junior Researcher
Mirzo Ulugbek str., 83, Tashkent, 100125
O. I. Radjabov
Institute of Bioorganic Chemistry
Uzbekistan
Uzbekistan
Otabek I. Radjabov, Senior Researcher, Candidate of Chemical Sciences
Mirzo Ulugbek str., 83, Tashkent, 100125
A. S. Turaev
Institute of Bioorganic Chemistry
Uzbekistan
Uzbekistan
Abbaskhan S. Turaev, Academician, Doctor of Chemical Sciences, Director
Mirzo Ulugbek str., 83, Tashkent, 100125
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Filatova A.V., Azimova L.B., Radjabov O.I., Turaev A.S. Study of polysaccharides of Foeniculum vulgare for use as a biologically active food supplement. Food systems. 2025;8(3):423-430. (In Russ.) https://doi.org/10.21323/2618-9771-2025-8-3-423-430
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