foodsystFood systemsПищевые системы2618-97712618-7272Федеральный научный центр пищевых систем им. В.М. Горбатова РАН10.21323/2618-9771-2025-8-3-423-430foodsyst-861Research ArticleСтатьиStudy of polysaccharides of Foeniculum vulgare for use as a biologically active food supplementИсследование полисахаридов Foeniculum vulgare для применения в качестве биологически активной добавки к пищеhttps://orcid.org/0000-0002-7911-1461ФилатоваА. В.FilatovaA. V.

Филатова Альбина Васильевна — ведущий научный сотрудник, доктор технических наук

100125, Ташкент, ул. Мирзо Улугбека, 83

Albina V. Filatova, Leading Researcher, Doctor of Technical Science

Mirzo Ulugbek str., 83, Tashkent, 100125

albfil@mail.ruhttps://orcid.org/0000-0002-0673-5396АзимоваЛ. Б.AzimovaL. B.

Азимова Луиза Бахтияровна — младший научный сотрудник

100125, Ташкент, ул. Мирзо Улугбека, 83

Luiza B. Azimova, Junior Researcher

Mirzo Ulugbek str., 83, Tashkent, 100125

luiza8181@mail.ruhttps://orcid.org/0000-0001-9196-7169РаджабовО. И.RadjabovO. I.

Раджабов Отабек Искандарович — старший научный сотрудник, кандидат химических наук

100125, Ташкент, ул. Мирзо Улугбека, 83

Otabek I. Radjabov, Senior Researcher, Candidate of Chemical Sciences

Mirzo Ulugbek str., 83, Tashkent, 100125

ximik_07@mail.ruhttps://orcid.org/0000-0003-2915-9237ТураевА. С.TuraevA. S.

Тураев Аббасхан Сабирханович — академик, доктор химических наук, директор

100125, Ташкент, ул. Мирзо Улугбека, 83

Abbaskhan S. Turaev, Academician, Doctor of Chemical Sciences, Director

Mirzo Ulugbek str., 83, Tashkent, 100125

abbaskhan@mail.ruИнститут биоорганической химииУзбекистанInstitute of Bioorganic ChemistryUzbekistan20251610202583423430Copyright © Filatova A.V., Azimova L.B., Radjabov O.I., Turaev A.S., 20252025Филатова А.В., Азимова Л.Б., Раджабов О.И., Тураев А.С.Filatova A.V., Azimova L.B., Radjabov O.I., Turaev A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.fsjour.com/jour/article/view/861

The mineral composition of the phytomass of common fennel (Foeniculum vulgarе) growing in the mountainous regions of Uzbekistan has been studied. A high content of biogenic elements, including calcium, potassium, magnesium, phosphorus, sodium and iron has been established in this type of raw material. Water-soluble polysaccharides have been isolated from Foeniculum vulgare. The carbohydrate content in the purified polysaccharide samples was tested by the phenol-sulfuric acid method and amounted to 95.0–99.4%. The analysis of the monosaccharide composition showed that the neutral polysaccharide composition is represented by monosaccharides in the following composition: glucose — 54.1±2.5%, galactose — 21.5±0.95%, mannose — 12.9±0.61%. The composition of the acidic polysaccharide is represented by the following monosaccharides: glucose — 42.6±2.11%, galactose — 22.9±1.13%, mannose — 14.5±0.68%. The results of IR spectroscopic studies showed that the isolated polysaccharides consist mainly of α-linked pyranose units. The study of acute toxicity of polysaccharides showed that they belong to class V of practically non-toxic compounds. LD50 when administered orally to mice was more than 10000 mg/kg. The therapeutic action of Foeniculum vulgare polysaccharides had a positive effect on the lipid background of rabbits with atherosclerosis caused by cholesterol, as well as a hypercoagulation effect in rabbits with atherosclerosis both by the extrinsic pathway of blood coagulation and by the intrinsic one due to thrombin inhibition. The revealed biological activity of polysaccharides of Foeniculum vulgare will serve to develop a biologically active supplement based on them.

Изучен минеральный состав фитомассы фенхеля обыкновенного (Foeniculum vulgarе), произрастающего в горных районах Узбекистана. В данном виде сырья установлено высокое содержание биогенных элементов, в том числе кальция, калия, магния, фосфора, натрия и железа. Из Foeniculum vulgare выделены водорастворимые полисахариды. Содержание углеводов в очищенных образцах полисахаридов исследовано фенол-сернокислотным методом и составило 95,0–99,4%. Анализ моносахаридного состава показал, что нейтральный полисахаридный состав представлен моносахаридами в следующем составе: глюкоза — 54,1±2,5%, галактоза — 21,5±0,95%, манноза — 12,9±0,61%. Состав кислого полисахарида представлен следующими моносахаридами: глюкоза — 42,6±2,11%, галактоза — 22,9±1,13%, манноза — 14,5±0,68%. Результаты ИК‑спектроскопических исследований показали, что выделенные полисахариды состоят в основном из α-связанных пиранозных звеньев. Изучение острой токсичности полисахаридов показало, что они относятся к V классу практически нетоксичных соединений. ЛД50 при пероральном введении мышам составила более 10000 мг/кг. Лечебное действие полисахаридов Foeniculum vulgare оказало положительное влияние на липидный фон кроликов с атеросклерозом, вызванным холестерином, а также гиперкоагуляционный эффект у кроликов с атеросклерозом как по внешнему пути свертывания крови, так и по внутреннему за счет ингибирования тромбина. Выявленная биологическая активность полисахаридов фенхеля обыкновенного позволит разработать на их основе биологически активную добавку.

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The authors declare that there are no conflicts of interest present.