foodsystFood systemsПищевые системы2618-97712618-7272Федеральный научный центр пищевых систем им. В.М. Горбатова РАН10.21323/2618-9771-2025-8-1-106-113foodsyst-712Research ArticleСтатьиBiochemical changes in rats after treatment with soft drink and menthol flavoured candyБиохимические изменения у крыс после употребления газированного напитка и ментоловых конфетhttps://orcid.org/0000-0002-9489-8725ИсоджиЭ. Ф.IsojeE. F.

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dina_saadi@mtu.edu.iqКафедра биохимии, факультет естественных наук, Университет науки и технологий штата ДельтаНигерияDepartment of Biochemistry, Faculty of Science, Delta State University of Science and TechnologyNigeriaКафедра биохимии, факультет естественных наук, Университет штата ДельтаНигерияDepartment of Biochemistry, Faculty of Science, Delta State UniversityNigeriaКафедра систем кондиционирования воздуха, инженерный факультет, Университет Варит Аль-АнбияРоссияDepartment of Air Conditioning Engineering, Faculty of Engineering, Warith Al-Anbiyaa UniversityRussian FederationКафедра химии, факультет естественных наук, Университет науки и технологий штата ДельтаНигерияDepartment of Chemistry, Faculty of Science, Delta State University of Science and TechnologyNigeriaХимический факультет, Колледж естественных наук Университет Аль-НахраинИракDepartment of Chemistry, College of SciencesIraqКафедра биохимии, факультет естественных наук, Университет науки и технологий штата ДельтаНигерияDepartment of Biochemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria 2 Department of Biochemistry, Faculty of Science, Delta State UniversityNigeriaКафедра медицинских лабораторных наук, факультет естественных наук, Университет штата ДельтаНигерияDepartment of Medical Laboratory Science, Delta State UniversityNigeriaКафедра городского и регионального планирования, факультет экологических наук, Университет науки и технологий штата ДельтаНигерияDepartment of Medical Laboratory Science, Delta State UniversityNigeriaЦентр оперативных исследований в области здравоохранения, Ближневосточный университетКипрOperational Research Centre in Healthcare, Near East UniversityCyprusКафедра естественных наук, факультет пищевой науки и технологии, Государственный университет науки и технологии ДельтаНигерияFaculty of Science, Department of Food Science and Technology, Delta State University of Science and TechnologyNigeriaФакультет химической промышленности, Технологический институт Багдада, Средний технический университетРоссияDepartment of Chemical Industries, Institute of Technology-Baghdad, Middle Technical UniversityRussian Federation20252504202581106113Copyright © Isoje E.F., Okoro I.O., Ali B., Edo G.I., Yousif E., Okpoghono J., Okoro E.O., Okom S.U., Essaghah A.A., Umar H., Owheruo J.O., Akpoghelie P.O., Ahmed D.S., 20252025Исоджи Э.Ф., Окоро И.О., Али Б.А., Эдо Г.И., Юсиф Э., Окпогхоно Д., Окоро Э.О., Оком С.У., Эссагхах А.Э., Умар Х., Оверуо Д.О., Акпогели П.О., Ахмед Д.С.Isoje E.F., Okoro I.O., Ali B., Edo G.I., Yousif E., Okpoghono J., Okoro E.O., Okom S.U., Essaghah A.A., Umar H., Owheruo J.O., Akpoghelie P.O., Ahmed D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.fsjour.com/jour/article/view/712

The current study looked at the biochemical variations that occurred in rats after they were given menthol flavoured candies and soft drinks. Seventy male Wistar albino rats in total were acquired, split up into ten treatments of seven rats each, and treated with the following regimen for forty-two days. Group 1 is the control. Groups 2, 3, and 4 received 8, 5, and 2.5 ml of La Casera/kg body weight. Groups 5, 6, and 7 received 0.34, 0.22, and 0.11 g of Tom-Tom/kg body weight. The dosages for groups 8, 9, and 10 were 8, 5, and 2.5 ml of La Casera/kg body weight, as well as 0.34, 0.22, and 0.11 g of Tom-Tom/kg body weight correspondingly. The results showed that the groups given Tom-Tom and La Casera had lower levels of total protein (TP) and albumin (Alb), and significantly (p < 0.05) higher serum levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total cholesterol (T-Chol), triacylglycerol (TAG), and low-density lipoprotein cholesterol (LDL–C). Furthermore, there was a substantial (p < 0.05) increase in the serum levels of TP, Alb, and ALT between groups 7 and 5. Prolonged use of Tom-Tom mixed with La Casera should be avoided due to the detrimental alterations in biochemical parameters and subsequent health repercussions.

В текущем исследовании изучались биохимические изменения, имевшие место у крыс после того, как им давали ментоловые конфеты и газированный напиток. Всего было получено семьдесят самцов крыс-альбиносов породы Вистар, разделенных на десять групп по семь крыс в каждой. Эксперимент проводился по описанной ниже схеме в течение сорока двух дней. Группа 1 — контрольная. Группы 2, 3 и 4 получали 8, 5 и 2,5 мл напитка «La Casera»/кг веса. Группы 5, 6 и 7 получали 0,34, 0,22 и 0,11 г конфет «Tom-Tom»/кг веса. Дозировки для групп 8, 9 и 10 составляли 8, 5 и 2,5 мл напитка «La Casera»/кг веса, а также 0,34, 0,22 и 0,11 г конфет «Tom-Tom»/кг веса, соответственно. Результаты показали, что в сыворотке крови у крыс, которым давали «Tom-Tom» и «La Casera», наблюдались более низкие уровни общего белка (TP) и альбумина (Alb), и значительно (p < 0,05) более высокие уровни аланинаминотрансферазы (ALT), аспартатами- нотрансферазы (AST), щелочной фосфатазы (ALP), общего холестерина (T-Chol), триглицеридов (TAG) и холестерина липопротеинов низкой плотности (LDL–C). Кроме того, между группами 7 и 5 наблюдалось существенное (p < 0,05) увеличение сывороточных уровней TP, Alb и ALT. Вследствие пагубных изменений в биохимических параметрах и во избежание отрицательных последствий для здоровья следует избегать длительного употребления конфет «Tom-Tom» совместно с напитком «La Casera».

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The authors declare that there are no conflicts of interest present.