References

foodsyst

Food systems

Пищевые системы

2618-97712618-7272

Федеральный научный центр пищевых систем им. В.М. Горбатова РАН

10.21323/2618-9771-2025-8-1-73-80

foodsyst-708

Research Article

Статьи

Lawsonia inermis extract: Antibacterial, anticancer and antioxidant properties

Экстракт лавсонии обыкновенной: антибактериальные, противораковые и антиоксидантные свойства

https://orcid.org/0000-0003-2082-9425

Ревати

С.

Revathi

Ревати Симейсами - научный сотрудник

Чибинонг сити, Богор, 1691

Тел.: +91–908–053–11–24

Seemaisamy Revathi, Researcher

Cibinong city, Bogor, 1691

Tel.: +91–908–053–11–24

reva001@brin.go.id

Нассер

Э. К.

Nasser

E. K.

Нассер Эльхам К. - адъюнкт-профессор

Басра, 61004

Tel.: +964–773–564–00–90

Elham K. Nasser, Associate Professor

Basrah, 61004

Tel.: +964–773–491–31–98

elham.nasser@uobasrah.edu.iq

https://orcid.org/0000-0001-8329-8436

Вафаа

Х. Х.

Wafaa

H. K.

Вафаа Х. Хассаф - научный сотрудник

Басра, 61004

Tel.: +964–773–564–00–90

H. Khassaf Wafaa, Researcher

Basrah, 61004

Tel.: +964–773–564–00–90

wafaa.khassaf@uobasrah.edu.iq

https://orcid.org/0000-0001-7750-5988

Алтемими

А. Б.

Altemimi

A. B.

Ал-Темими Аммар Б. - адъюнкт-профессор

Басра, 61004

Tel.: +964–770–567–37–84

Ammar B. Altemimi, Associate Professor

Basrah, 61004

Tel.: +964–773–564–00–90

ammar.ramddan@uobasrah.edu.iq

https://orcid.org/0000-0002-2407-4747

Сутикно

С.

Sutikno

Сутикно Сутикно - научный сотрудник

Чибинонг сити, Богор, 1691

Тел.: +62–898–657–63–00

Sutikno Sutikno, Researcher

Cibinong city, Bogor, 1691

Tel.: +62–898–657–63–00

suti009@brin.go.id

https://orcid.org/0000-0002-9185-0400

Картика

Т.

Kartika

Картика Титик - научный сотрудник

Чибинонг сити, Богор, 1691

Тел.: +62–812–7072–19–27

Titik Kartika, Researcher

Cibinong city, Bogor, 1691

Tel.: +62–812–7072–19–27

titik.kartika@brin.go.id

https://orcid.org/0000-0002-3969-0067

Гусвенриво

И.

Guswenrivo

Гусвенриво Ихсан - научный сотрудник

Чибинонг сити, Богор, 1691

Тел.: +62–813–1001–97–63

Ikhsan Guswenrivo, Researcher

Cibinong city, Bogor, 1691

Tel.: +62–813–1001–97–63

ikhsan.guswenrivo@brin.go.id

https://orcid.org/0000-0002-1737-5920

Авлкадр

Ф. Х.

Awlqadr

F. H.

Аулькадр Фарханг Х. - научный сотрудник

П/я 70–236, Сулеймания

Тел.: +96–477–014–209–62

Farhang H. Awlqadr, Researcher

P. O. Box: 70–236, Sulaymaniyah

Tel.: +96–477–014–209–62

Farhang.hamid.a@spu.edu.iq

https://orcid.org/0000-0002-7012-6667

Абедельмаксуд

Т. Г.

Abedelmaksoud

T. G.

Абедельмаксуд Т. Г. - адъюнкт-профессор

12613, Гиза, ул. Гамаа, 1

Тел.: +2–0110–144–12–80

Tarek G. Abedelmaksoud, Associate Professor

1, Gamaa Street, Giza, 12613

Tel.: +2–0110–144–12–80

tareekgamal_88@agr.cu.edu.eg

Исследовательский центр прикладной зоологии, Научно-исследовательская организация в области наук о жизни и окружающей среде, Национальное агентство исследований и инноваций (BRIN)ИндонезияResearch Center for Applied Zoology, Research Organization for Life Science and Environment, National Research and Innovation Agency (BRIN)Indonesia

Кафедра пищевых наук, Сельскохозяйственный колледж, Университет БасрыИракDepartment of Food Science, College of Agriculture, University of Basrah, Basrah Iraq 3 Date Palm Research Centre, University of BasrahIraq

Исследовательский центр финиковой пальмы, Университет БасрыИракDate Palm Research Centre, University of BasrahIraq

Кафедра пищевых наук, Сельскохозяйственный колледж, Университет БасрыРоссияDepartment of Food Science, College of Agriculture, University of BasrahRussian Federation

Технический колледж прикладных наук Халабджи, Исследовательский центр Халабджи, Сулейманский политехнический университет СулейманияИракFood Science and Quality Control, Halabja Technical College, Sulaimani Polytechnic UniversityIraq

Кафедра пищевых наук, Сельскохозяйственный факультет, Каирский университетЕгипетFood Science Department, Faculty of Agriculture, Cairo UniversityEgypt

2025

25042025

817380

2025

Ревати С., Нассер Э.К., Вафаа Х.Х., Алтемими А.Б., Сутикно С., Картика Т., Гусвенриво И., Авлкадр Ф.Х., Абедельмаксуд Т.Г.

Revathi S., Nasser E.K., Wafaa H.K., Altemimi A.B., Sutikno S., Kartika T., Guswenrivo I., Awlqadr F.H., Abedelmaksoud T.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.fsjour.com/jour/article/view/708

Henna, scientifically known as Lawsonia inermis, is long used for its therapeutic benefits in several civilisations. This study examines the antibacterial, anticancer, and antioxidant properties of the leaf extract from L. inermis. The phytochemical study indicated the existence of alkaloids, flavonoids, glycosides, phenolic compounds, and tannins. GC–Mass Spectrometry detected notable bioactive chemicals, including tetracosamethyl-cyclododecasiloxane and cyclohexasiloxane. The extracts demonstrated strong antioxidant properties, as evidenced by their values of 254.32 and 121.25%, as well as their high FRAP values, demonstrating their effective ability to scavenge radicals. The antibacterial effectiveness, assessed by the disc-diffusion technique, demonstrated substantial inhibition zones against both Gram positive and Gram-negative microorganisms. The MTT experiment exhibited significant anticancer efficacy against MCF‑7 breast cancer cell lines, with an IC50 value of 1.682 μg/mL. The results indicate that extracts from L. inermis contain significant bioactive substances that have the potential to be utilised in the development of innovative medications aimed at addressing oxidative stress, bacterial infections, and cancer.

Хна (хенна), известная в науке как Lawsonia inermis, уже давно применяется во многих цивилизациях благодаря своим лечебным свойствам. В исследовании изучены антибактериальные, противораковые и антиоксидантные свойства экстракта листьев L. inermis. Фитохимическое исследование растения показало наличие алкалоидов, флавоноидов, гликозидов, фенольных соединений и танинов. С помощью ГХ‑масс-спектрометрии были обнаружены биологически активные химические вещества, в том числе тетракозаметил-циклододекасилоксан и циклогексасилоксан. Экстракты продемонстрировали сильные антиоксидантные свойства, о чем свидетельствуют уровни их содержания — 254,32 и 121,25%, а также их высокие значения восстановления флуоресценции после фотообесцвечивания (FRAP), демонстрирующие их эффективную способность захватывать радикалы. Антибактериальная эффективность, оцененная с помощью дискодиффузионного метода, продемонстрировала весьма крупные зоны ингибирования роста как грамположительных, так и грамотрицательных микроорганизмов. Анализ с MTT показал значительную противораковую эффективность против линий клеток рака груди MCF‑7 со значением IC50 1,682 мкг/мл. Результаты показывают, что экстракты L. inermis содержат значительные биоактивные вещества, которые могут быть использованы при разработке инновационных лекарств, направленных на борьбу с окислительным стрессом, бактериальными инфекциями и раком.

фитотерапиябиологически активные соединенияокислительный стрессцитотоксические эффектыисследование природного продуктафитохимический скрининг

herbal medicinebioactive compoundsoxidative stresscytotoxic effectsnatural product researchphytochemical screening

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The authors declare that there are no conflicts of interest present.