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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">foodsyst</journal-id><journal-title-group><journal-title xml:lang="en">Food systems</journal-title><trans-title-group xml:lang="ru"><trans-title>Пищевые системы</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2618-9771</issn><issn pub-type="epub">2618-7272</issn><publisher><publisher-name>Федеральный научный центр пищевых систем им. В.М. Горбатова РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21323/2618-9771-2023-6-2-224-232</article-id><article-id custom-type="elpub" pub-id-type="custom">foodsyst-272</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Study of the process of hydrolysis of milk proteins using enzyme preparations of domestic and production</article-title><trans-title-group xml:lang="ru"><trans-title>Исследование процесса гидролиза белков молока с использованием ферментных препаратов отечественного производства</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3848-7478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семенова Елена Сергеевна — младший научный сотрудник, лаборатория опытно-экспериментальных технологических исследований</p><p>143500, Московская область, Истра, ул. Московская, 48Тел.: +7–498–313–03–96</p></bio><bio xml:lang="en"><p>Elena S. Semenova, Junior Researcher, Laboratory of Experimental Technological Research</p><p>48, Moskovskaya str., Moscow region, 143500, Istra, RussiaTel.: +7–498–313–03–96</p></bio><email xlink:type="simple">lab6@niidp.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2878-8069</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симоненко</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonenko</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симоненко Елена Сергеевна — кандидат технических наук, младший научный сотрудник, лаборатория технологий продуктов питания детей и дошкольного и школьного возраста</p><p>143500, Московская область, Истра, ул. Московская, 48Тел.: +7–498–313–03–96</p></bio><bio xml:lang="en"><p>Elena S. Simoneko, Candidate of Technical Sciences, Junior Researcher, Laboratory of Food Technologies for Children and Preschool and School Age</p><p>48, Moskovskaya str., Moscow region, 143500, Istra, RussiaTel.: +7–498–313–03–96</p></bio><email xlink:type="simple">nir@niidp.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6999-5048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симоненко</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonenko</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симоненко Сергей Владимирович — доктор технических наук, директор</p><p>143500, Московская область, Истра, ул. Московская, 48Тел.: +7–498–313–03–96</p></bio><bio xml:lang="en"><p>Sergey V. Simoneko, Doctor of Technical Sciences, Director</p><p>48, Moskovskaya str., Moscow region, 143500, Istra, RussiaTel.: +7–498–313–03–96</p></bio><email xlink:type="simple">dir@niidp.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2689-6098</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зорин</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zorin</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зорин Сергей Николаевич — кандидат биологических наук, старший научный сотрудник, лаборатория пищевых биотехнологий и специализированных продуктов</p><p>109240, Москва, Устьинский проезд, 2/14Тел.: +7–495–698–53–71</p></bio><bio xml:lang="en"><p>Sergey N. Zorin, Candidate of Biological Sciences, Senior Researcher, Laboratory of Food Biotechnologies and Specialized Products</p><p>2/14, Ustyinsky proezd, 109240, Moscow, RussiaTel.: +7–495–698–53–71</p></bio><email xlink:type="simple">zorin@ion.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9755-6002</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петров Никита Александрович — инженер, лаборатория пищевых биотехнологий и специализированных продуктов</p><p>109240, Москва, Устьинский проезд, 2/14Тел.: +7–903–794–87–14</p></bio><bio xml:lang="en"><p>Nikita A. Petrov, Engineer, Laboratory of Food Biotechnologies and Specialized Products</p><p>2/14, Ustyinsky proezd, 109240, Moscow, RussiaTel.: +7–903–794–87–14</p></bio><email xlink:type="simple">petrov-nikita-y@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3237-7967</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазо</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazo</surname><given-names>V. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мазо Владимир Кимович — доктор биологических наук, профессор, ведущий научный сотрудник, лаборатория пищевых биотехнологий и специализированных продуктов</p><p>109240, Москва, Устьинский проезд, 2/14Тел.: +7–495–698–53–71</p></bio><bio xml:lang="en"><p>Vladimir K. Mazo, Doctor of Biological Sciences, Professor, Leading Researcher, Laboratory of Food Biotechnologies and Specialized Products</p><p>2/14, Ustyinsky proezd, 109240, Moscow, RussiaTel.: +7–495–698–53–71</p></bio><email xlink:type="simple">mazo@ion.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт детского питания — филиал Федерального исследовательского центра питания, биотехнологии и безопасности пищи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute of Baby Food — a branch Federal Research Center of Nutrition, Biotechnology and Food Safety</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральный исследовательский центр питания, биотехнологии и безопасности пищи</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Nutrition, Biotechnology and Food Safety</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>13</day><month>07</month><year>2023</year></pub-date><volume>6</volume><issue>2</issue><fpage>224</fpage><lpage>232</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Semenova E.S., Simonenko E.S., Simonenko S.V., Zorin S.N., Petrov N.A., Mazo V.K., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Семенова Е.С., Симоненко Е.С., Симоненко С.В., Зорин С.Н., Петров Н.А., Мазо В.К.</copyright-holder><copyright-holder xml:lang="en">Semenova E.S., Simonenko E.S., Simonenko S.V., Zorin S.N., Petrov N.A., Mazo V.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.fsjour.com/jour/article/view/272">https://www.fsjour.com/jour/article/view/272</self-uri><abstract><p>Due to the high prevalence of allergic diseases among the children, especially when transiting a child to bottle feeding at an early age, the development of dairy and other food products with reduced allergenicity is of high relevance and true importance nowadays. Meanwhile Russia still lacks sufficient production of raw materials and ingredients to create home-produced specialized food, including designated babies’ and children’s food. The use of whey milk proteins for the production of baby food has its advantage, as whey proteins feature pretty high digestibility and bioavailability: after eating the food based on whey proteins, the concentration of amino acids and peptides in the blood increases dramatically already within the first hour. However, it should be kept in mind that allergy to cow’s milk proteins is the most common symptom of food allergy, which is particularly often diagnosed in early postnatal age. Technological approaches to reduction of the potential allergenicity of the protein component shall take a leading place in the system of food control and food safety of children’s dairy products. The most efficient and widely used technological approach to reduce the potential allergenicity of food protein is the elimination of its antigenic structures, which approach makes it possible to include this protein into the composition of specialized food, which is intended for the people who suffer from food allergies or for the people exposed to the allergy risk. The allergenicity is reduced by means of enzymatic hydrolysis in combination with membrane processing of the obtained hydrolyzate. To obtain a peptide module with pre-determined physical and chemical parameters, an appropriate selection of initial protein, application of various enzymes, and ranging of technological parameters like pH, temperature, exposure time, enzyme-substrate ratio and other parameters is required.</p></abstract><trans-abstract xml:lang="ru"><p>В связи с высокой распространенностью аллергических заболеваний у детей, особенно при переводе на искусственное вскармливание в раннем возрасте, актуальным направлением является разработка молочных и других продуктов питания с пониженной аллергенностью. При этом в России отсутствуют достаточные объемы производства сырья и ингредиентов для создания отечественной специализированной пищевой продукции, включая продукцию, предназначенную для детей. Использование сывороточных белков молока в производстве продуктов детского питания имеет преимущество, поскольку белки молочной сыворотки обладают достаточно высокой переваримостью и биодоступностью: после приема пищевых продуктов на основе сывороточных белков концентрация аминокислот и пептидов в крови резко возрастает уже в течение первого часа. Однако, следует учитывать, что аллергия к белкам коровьего молока является наиболее распространенным проявлением пищевой аллергии, особенно часто выявляемым в раннем постнатальном возрасте. Технологические подходы к снижению потенциальной аллергенности белкового компонента должны занять ведущее место в системе контроля и обеспечения безопасности детской молочной пищевой продукции. Наиболее эффективным и широко применяемым технологическим подходом к снижению потенциальной аллергенности пищевого белка для использования его в составе специализированных пищевых продуктов для питания лиц, страдающих пищевой аллергией или входящих в группу риска, является элиминация его антигенных структур. Она проводится путем ферментативного гидролиза, в сочетании с мембранной обработкой получаемого гидролизата. Для получения пептидного модуля с заданными физико-химическими параметрами требуется соответствующий выбор исходного белка, использование различных ферментов и варьирование такими технологическими параметрами, как уровень рН, температура, продолжительность экспозиции, фермент-субстратное соотношение и другие.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сывороточные белки</kwd><kwd>гидролизат</kwd><kwd>ферментный препарат</kwd><kwd>молекулярномассовое распределение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>whey proteins</kwd><kwd>hydrolyzate</kwd><kwd>enzyme preparation</kwd><kwd>molecular weight distribution</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена на базе НИИ детского питания - филиала ФГБУН «ФИЦ питания и биотехнологии» в рамках обеспечения условий выполнения работ гранта в форме субсидии на обеспечение проведения российскими научными организациями и (или) образовательными организациями высшего образования совместно с иностранными организациями научных исследований в рамках обеспечения реализации программы двух- и многостороннего научно-технологического взаимодействия, по соглашению между ФГБУН «ФИЦ питания и биотехнологии» и Минобрнауки России от 02 октября 2022 года № 075-15-2022-1211 по теме: «Разработка технологии получения специализированных молочных продуктов с пониженной аллергенностью для детского питания на основе гидролизатов молочных белков».</funding-statement><funding-statement xml:lang="en">The research was conducted at the Research Institute of Baby Nutrition — a branch of the “Federal Research Center for Nutrition and Biotechnology” within the framework of ensuring the conditions for performing the work of a grant in the form of a subsidy for: ensuring that Russian scientific organizations and (or) educational organizations conduct higher education together with foreign organizations of scientific research as part of providing implementation of the program of bilateral and multilateral scientific and technological cooperation, according to the contract between the Federal State Budgetary Institution “Federal Research Center for Nutrition and Biotechnology” and the Ministry of Education and Science of Russia dated October 02, 2022 No. 075–15–2022–1211 on the topic: “Development of a technology for obtaining specialized dairy products with reduced allergenicity for baby food based on milk protein hydrolysates”.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Харитонов, В. 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