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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">foodsyst</journal-id><journal-title-group><journal-title xml:lang="en">Food systems</journal-title><trans-title-group xml:lang="ru"><trans-title>Пищевые системы</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2618-9771</issn><issn pub-type="epub">2618-7272</issn><publisher><publisher-name>Федеральный научный центр пищевых систем им. В.М. Горбатова РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21323/2618-9771-2021-4-4-278-285</article-id><article-id custom-type="elpub" pub-id-type="custom">foodsyst-136</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Glycation end products and technological aspects of reducing immunogenicity of specialized food products for nutrition of athletes</article-title><trans-title-group xml:lang="ru"><trans-title>Конечные продукты гликирования и технологические аспекты снижения иммуногенности специализированных пищевых продуктов для питания спортсменов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1237-5147</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобелькова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobelkova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кобелькова Ирина Витальевна — кандидат медицинских наук, ведущий научный сотрудник, лаборатория спортивной антропологии и нутрициологии; Доцент</p><p>109240, Москва Устьинский пр., 2/14с1125371, Москва, Волоколамское ш., 91Тел.: +7–910–406–40–31</p></bio><bio xml:lang="en"><p>Irina V. Kobelkova, Candidate of Medical Sciences, Leading Researcher, Laboratory of Sports Anthropology and Nutritionology; Docent</p><p>Ustinsky pr., 2/14с1, 109240, MoscowVolokolamsk Highway, 91, 125371, MoscowTel.: + 7–910–406–40–31</p></bio><email xlink:type="simple">irinavit66@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2279-648X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелева</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Korosteleva</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коростелева Маргарита Михайловна — кандидат медицинских наук, старший научный сотрудник, лаборатория спортивной антропологии и нутрициологии; Доцент, Кафедра управления сестринской деятельностью Медицинского института</p><p>109240, Москва, Устьинский пр., 2/14с1117198, Москва, ул. Миклухо-Маклая, 6Тел.: +7–985–567–78–22</p></bio><bio xml:lang="en"><p>Margarita M. Korosteleva, Candidate of Medical Sciences, Senior Researcher, Laboratory of Sports Anthropology and Nutritionology; Docent, Department of Nursing Management, Medical Institute</p><p>Ustinsky pr., 2/14с1, 109240, MoscowMiklukho-Maclay str., 6, 117198, MoscowTel.: +7–985–567–78–22</p></bio><email xlink:type="simple">korosrel@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2259-1222</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитюк</surname><given-names>Д. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikityuk</surname><given-names>D. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитюк Дмитрий Борисович — доктор медицинских наук, профессор, член-корреспондент РАН, директор; Профессор, кафедра оперативной хирургии и топографической анатомии</p><p>109240, Москва, Устьинский пр., 2/14с1119992, Москва, ул. Россолимо 15/13 с. 1Тел.: +7–495–695–53–60</p></bio><bio xml:lang="en"><p>Dmitry B. Nikityuk, Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Director; Professor, Department of Operative Surgery and Topographic Anatomy</p><p>Ustinsky pr., 2/14с1, 109240, MoscowRossolimo str., 15/13(1), 119992, MoscowTel.: +7–495–695–53–60</p></bio><email xlink:type="simple">nikitjuk@ion.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6742-8528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобелькова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobelkova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кобелькова Мария Сергеевна — врач</p><p>119146, Москва, 2-я Фрунзенская улица, д. 4Тел. +7–915–410–78–74</p></bio><bio xml:lang="en"><p>Maria S. Kobelkova, Doctor</p><p>2nd Frunzenskaya street, 4, 119146, MoscowTel. +7–915–410–78–74</p></bio><email xlink:type="simple">kobelkovams@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральный исследовательский центр питания, биотехнологии и безопасности пищи; Академия постдипломного образования<country>Россия</country></aff><aff xml:lang="en">Federal Research Center for Nutrition, Biotechnology and Food Safety; Academy of Postgraduate Education<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральный исследовательский центр питания, биотехнологии и безопасности пищи; Российский университет дружбы народов<country>Россия</country></aff><aff xml:lang="en">Federal Research Center for Nutrition, Biotechnology and Food Safety; Peoples’ Friendship University of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Федеральный исследовательский центр питания, биотехнологии и безопасности пищи; Первый Московский государственный медицинский университет имени И. М. Сеченова<country>Россия</country></aff><aff xml:lang="en">Federal Research Center for Nutrition, Biotechnology and Food Safety; I.M. Sechenov First Moscow State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">«Поликлиника № 2» Управления делами Президента Российской Федерации<country>Россия</country></aff><aff xml:lang="en">“Polyclinic No. 2” of the Administrative Department of the President of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>05</day><month>01</month><year>2022</year></pub-date><volume>4</volume><issue>4</issue><fpage>278</fpage><lpage>285</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kobelkova I.V., Korosteleva M.M., Nikityuk D.B., Kobelkova M.S., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Кобелькова И.В., Коростелева М.М., Никитюк Д.Б., Кобелькова М.С.</copyright-holder><copyright-holder xml:lang="en">Kobelkova I.V., Korosteleva M.M., Nikityuk D.B., Kobelkova M.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.fsjour.com/jour/article/view/136">https://www.fsjour.com/jour/article/view/136</self-uri><abstract><p>Food allergy, which affects about 8% of children and 5% of adults in the world, is one of the major global health problems, and allergen control is an important aspect of food safety. According to the FALCPA (Food Allergen Labeling and Consumer Protection Act of 2004 FDA), more than 160 foods can cause allergic reactions, with eight of them responsible for 90% of all food allergies in the United States, including milk, eggs, wheat, peanuts, soybeans, tree nuts, crustaceans and fish, also known as the Big 8. Most foods that are sources of obligate allergens are heat treated before consumption, which can trigger the Maillard reaction, which produces glycation end products. Symptoms of food sensitization are known to significantly affect the quality of life, gut microbial diversity and adaptation potential. In particular, in athletes, this can be expressed in a decrease in the effectiveness of the training process, which leads to poor endurance and athletic performance. In this regard, it seems relevant to study the effect of the Maillard reaction and AGEs on the immunogenicity of proteins and the possible relationship between these compounds and food allergy, as well as to develop measures to prevent the adverse effect of allergens on the body of a professional athlete and any other consumer.</p></abstract><trans-abstract xml:lang="ru"><p>Пищевая аллергия, которой страдают около 8% детей и 5% взрослых в мире, является одной из основных проблем мирового здравоохранения, а контроль аллергенов — важным аспектом безопасности пищевых продуктов. Согласно FALCPA (Food Allergen Labeling and Consumer Protection Act of 2004, FDA), более 160 продуктов питания могут вызывать аллергические реакции, при этом восемь из них ответственны за 90% всех случаев пищевой аллергии. К этим продуктам относятся молоко, яйцо, пшеница, арахис, соя, орех, ракообразные и рыба, также известные как «Большая восьмерка». Большинство пищевых продуктов, являющихся источником облигатных аллергенов, подвергается термической обработке перед употреблением. Это может вызывать инициацию реакции Майяра, в ходе которой образуются конечные продукты гликации. Известно, что симптомы пищевой сенсибилизации значительно влияют на качество жизни, разнообразие кишечного микробиома и адаптационный потенциал. В частности у спортсменов это может выражаться в снижении эффективности тренировочного процесса, что приводит к ухудшению показателей выносливости и спортивной производительности. В связи с этим представляется актуальным изучение влияния реакции Майяра и AGEs на иммуногенность белков и анализ возможной связи между этими соединениями и пищевой аллергией, а также разработка мероприятий по профилактике неблагоприятного воздействия аллергенов на организм профессионального спортсмена и любого другого потребителя.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>реакция Майяра</kwd><kwd>конечные продукты гликации</kwd><kwd>пищевая сенсибилизация</kwd><kwd>спортсмены</kwd><kwd>выносливость</kwd><kwd>кишечный микробиом</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Maillard reaction</kwd><kwd>glycation end products</kwd><kwd>food sensitization</kwd><kwd>athletes</kwd><kwd>endurance</kwd><kwd>gut microbiome</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Обзор подготовлен в рамках выполнения научно-исследовательской работы, выполненной на базе ФГБУН «ФИЦ питания и биотехнологии», по теме № 0529–2019–0059 «Разработка системы антропометрических и физиолого-биохимических методов оценки эффективности использования алиментарных факторов для повышения физической выносливости спортсменов различных видов спорта и выбор морфологических маркеров алиментарно-зависимых патологий».</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The review was prepared as part of the research work carried out on the basis of the Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”, on topic No. 0529–2019–0059 “Development of a system of anthropometric and physiological-biochemical methods for assessing the effectiveness of the use of alimentary factors to increase the physical endurance of athletes of various types of sports and the choice of morphological markers of alimentary-dependent pathologies”.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Somoza, V., Wenzel, E., Weiß, C., Clawin-Rädecker, I., Grübel, N., Erbersdobler, H. 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