<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">foodsyst</journal-id><journal-title-group><journal-title xml:lang="en">Food systems</journal-title><trans-title-group xml:lang="ru"><trans-title>Пищевые системы</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2618-9771</issn><issn pub-type="epub">2618-7272</issn><publisher><publisher-name>Федеральный научный центр пищевых систем им. В.М. Горбатова РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21323/2618-9771-2026-9-2-294-305</article-id><article-id custom-type="elpub" pub-id-type="custom">foodsyst-1101</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Nutritional profiles of Persea Americana and Telfairia occidentalis seeds: potential applications in food formulations</article-title><trans-title-group xml:lang="ru"><trans-title>Профили питательных свойств семян Persea Americana и Telfairia occidentalis: потенциальные виды применения в составе рецептур пищевых продуктов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4846-8513</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Экайода</surname><given-names>О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ekayoda</surname><given-names>O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Экайода О. – PhD, преподаватель </p><p>P.M.B. 1, Абрака, штат Дельта, Нигерия</p></bio><bio xml:lang="en"><p>Ovigueroye Ekayoda, PhD, Lecturer</p><p>P.M.B. 1, Abraka, Delta State, Nigeria</p></bio><email xlink:type="simple">kayovidex@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1303-3680</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кадири</surname><given-names>Х. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Kadiri</surname><given-names>H. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кадири Хелен Е. – PhD, преподаватель</p><p>P.M.B. 1, Абрака, штат Дельта, Нигерия</p></bio><bio xml:lang="en"><p>Helen E. Kadiri, PhD, Lecturer</p><p>P.M.B. 1, Abraka, Delta State, Nigeria</p></bio><email xlink:type="simple">Kadiri@delsu.edu.ng</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5841-0027</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Апиаму</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Apiamu</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Апиаму А. – PhD, преподаватель- исследователь, Кафедра биохимии, </p><p>P.M.B. 1, Абрака, штат Дельта, Нигерия</p></bio><bio xml:lang="en"><p>Augustine Apiamu, PhD, Lecturer/Researcher</p><p>P.M.B. 1, Abraka, Delta State, Nigeria</p></bio><email xlink:type="simple">aapiamu@delsu.edu.ng</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5886-1765</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Окпогоно</surname><given-names>Дж.</given-names></name><name name-style="western" xml:lang="en"><surname>Okpoghono</surname><given-names>J.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Окпохоно Дж. – PhD, преподаватель, Кафедра биохимии </p><p>P. M. B. 05, дорога Озоро-Квале, Озоро, штат Дельта, Нигерия</p></bio><bio xml:lang="en"><p>Joel Okpoghono, PhD, Lecturer</p><p>P. M. B. 05, Ozoro-Kwale Road, Ozoro, Delta State, Nigeria</p></bio><email xlink:type="simple">okpoghonoj@dsust.edu.ng</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра биохимии, факультет естественных наук, Университет штата Дельта</institution><country>Нигерия</country></aff><aff xml:lang="en"><institution>Department of Biochemistry, Faculty of Science, Delta State University</institution><country>Nigeria</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Факультет естественных наук, Университет штата Дельта</institution><country>Нигерия</country></aff><aff xml:lang="en"><institution>Department of Biochemistry, Faculty of Science, Delta State University</institution><country>Nigeria</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Факультет естественных наук, Университет Южной Дельты</institution><country>Нигерия</country></aff><aff xml:lang="en"><institution>Department of Biochemistry, Faculty of Science, Southern Delta University</institution><country>Nigeria</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>01</day><month>08</month><year>2026</year></pub-date><volume>9</volume><issue>2</issue><fpage>294</fpage><lpage>305</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ekayoda O., Kadiri H.E., Apiamu A., Okpoghono J., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Экайода О., Кадири Х.Э., Апиаму А., Окпогоно Д.</copyright-holder><copyright-holder xml:lang="en">Ekayoda O., Kadiri H.E., Apiamu A., Okpoghono J.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.fsjour.com/jour/article/view/1101">https://www.fsjour.com/jour/article/view/1101</self-uri><abstract><p>Underutilized plant seeds represent a valuable but often overlooked resource for improving food security, promoting sustainable agriculture, and expanding the availability of nutrient-dense ingredients. Avocado (Persea americana) and fluted pumpkin (Telfairia occidentalis) seeds have gained attention due to their health benefits and nutritional advantages. P. americana seeds are not agro-waste; rather, they are an excellent supplier of bioactive chemicals that may find use in the food and pharmaceutical industries. T. occidentalis seeds mostly re-cultivated for its consumable leaves are rich in antioxidants and other essential nutrients, serving functional roles and demonstrating diverse health-enhancing properties. This review investigates the nutritional profile of two underexploited seeds – P. americana seeds and T. occidentalis seeds – with emphasis on their nutritional composition, health benefits and approaches to emphasize their use as functional food components and their prospective incorporation into dietary supplements. To find pertinent research on the nutritional makeup of P. americana and T. occidentalis seeds, an organized search for literature was carried out across several web-based databases (Google Scholar, PubMed, ScienceDirect, Google Search Engine, Springer Link, and Web of Science). The seeds of P. americana and T. occidentalis exhibit a comparable nutritional profile which include macronutrient, mineral content, and phytochemical constituents that together provide their therapeutic benefits including antimicrobial, antioxidant, anti-obesity, anti-inflammatory, antidiabetic, anticancer, and enhancing fertility. Both seeds can be processed and effectively integrated into various food products, thereby improving their functional attributes. The review highlights the underutilized nutritional and functional potential of these seeds, providing scientific support for their incorporation into food formulations and value-added product development. Valorizing T. occidentalis and P. americana seeds could therefore contribute to waste reduction, economic diversification, and improved dietary quality, especially in regions where these crops are abundant.</p></abstract><trans-abstract xml:lang="ru"><p>Семена растений представляют собой ценный, но зачастую неиспользуемой ресурс, способный повысить продовольственную безопасность, развить устойчивую систему сельского хозяйства и увеличить потребительскую доступность ингредиентов, плотно насыщенных питательными веществами. Семя авокадо (Persea americana) и семена рифленой тыквы (Telfairia occidentalis) привлекли к себе внимание благодаря своим полезным для здоровья свойствам и питательной ценности. Семя P. americana не является сельскохозяйственным отходом; напротив, оно представляет собой отличный источник биологически активных веществ, которым можно найти применение в пищевой и фармацевтической промышленности. Семена T. occidentalis, в основном повторно культивируемые ради получения съедобных листьев, богаты антиоксидантами и другими необходимыми питательными веществами, выполняют функциональные задачи и обладают разнообразными свойствами, полезными для здоровья. В этой работе исследуется питательный профиль двух недооцененных семян – семян P. americana и семян T. occidentalis – с особым вниманием к их питательному составу, пользе для здоровья и подходам к их использованию в качестве функциональных пищевых компонентов, и перспективе их включения в пищевые добавки. Для поиска соответствующих исследований по питательному составу семян P. americana и T. occidentalis был проведен организованный поиск источников в нескольких веб-базах данных (Google Scholar, PubMed, ScienceDirect, Google Search Engine, Springer Link и Web of Science). Семена P. americana и T. occidentalis обладают сопоставимыми профилями питательных веществ, включающими макронутриенты, минералы и фитохимические компоненты, которые в совокупности обеспечивают их терапевтические свойства, включая антимикробное, антиоксидантное, антиадипозное, противовоспалительное, противодиабетическое, противораковое действие, а также повышение фертильности человека. Оба вида семян могут быть переработаны и эффективно интегрированы в различные пищевые продукты, тем самым улучшая функциональные свойства такового пищевого продукта. В статье подчеркивается недооцененность питательного и функционального потенциала этих семян, дается научное обоснование для их включения в пищевые рецептуры и разработки продуктов питания с добавленной стоимостью. Таким образом, использование семян T. occidentalis и P. americana может способствовать сокращению объема отходов, диверсификации экономики и улучшению качества питания, особенно в регионах, где эти культуры широко произрастают.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>съедобные семена</kwd><kwd>функциональные продукты</kwd><kwd>полезные свойства</kwd><kwd>состав питательных веществ</kwd><kwd>Persea americana</kwd><kwd>Telfairia occidentalis</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Edible seeds</kwd><kwd>functional food</kwd><kwd>health benefits</kwd><kwd>nutritional composition</kwd><kwd>Persea Americana</kwd><kwd>Telfairia occidentalis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gan, R. -Y., Lui, W. -Y., Wu, K., Chan, C. -L., Dai, S. -H., Sui, Z. -Q. et al. (2017). Bioactive compounds and bioactivities of germinated edible seeds and sprouts: An updated review. Trends in Food Science and Technology, 59, 1–14. https://doi.org/10.1016/j.tifs.2016.11.010</mixed-citation><mixed-citation xml:lang="en">Gan, R. -Y., Lui, W. -Y., Wu, K., Chan, C. -L., Dai, S. -H., Sui, Z. -Q. et al. (2017). Bioactive compounds and bioactivities of germinated edible seeds and sprouts: An updated review. Trends in Food Science and Technology, 59, 1–14. https://doi.org/10.1016/j.tifs.2016.11.010</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J., Ukperegbulem, J. K., Onyesom, I. (2024). Neuroprotective aftermath of Monodora myristica and Glycyrrhiza glabra against cassava diet containing vacuum gas oil induced brain injury in Wistar rats. Toxicology Report, 12, 244–252. https://doi.org/10.1016/j.toxrep.2024.02.001.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J., Ukperegbulem, J. K., Onyesom, I. (2024). Neuroprotective aftermath of Monodora myristica and Glycyrrhiza glabra against cassava diet containing vacuum gas oil induced brain injury in Wistar rats. Toxicology Report, 12, 244–252. https://doi.org/10.1016/j.toxrep.2024.02.001.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J., Igue, U. B., Isoje, F. E., Okom, S. U., Seigha, A. A., Erorun, M. (2024). Assessment of vitamins and minerals of rats fed with plantain-maize pudding prepared using edible plant leaves and metallic plates. Food Research, 8(4), 143–150. https://doi.org/10.26656/fr.2017.8(4).359.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J., Igue, U. B., Isoje, F. E., Okom, S. U., Seigha, A. A., Erorun, M. (2024). Assessment of vitamins and minerals of rats fed with plantain-maize pudding prepared using edible plant leaves and metallic plates. Food Research, 8(4), 143–150. https://doi.org/10.26656/fr.2017.8(4).359.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bhuyan, D. J., Alsherbiny, M. A., Perera, S., Low, M., Basu, A., Devi, O. A. et al. (2019). The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits. Antioxidants, 8(10), Article 426. https://doi.org/10.3390/antiox8100426.</mixed-citation><mixed-citation xml:lang="en">Bhuyan, D. J., Alsherbiny, M. A., Perera, S., Low, M., Basu, A., Devi, O. A. et al. (2019). The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits. Antioxidants, 8(10), Article 426. https://doi.org/10.3390/antiox8100426.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J. (2026). Preservative approaches, culinary and medicinal prospective mechanisms of herbs and spices: A compiled update. Heliyon, 12(1), Article e44306. https://doi.org/10.1016/j.heliyon.2025.e44306.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J. (2026). Preservative approaches, culinary and medicinal prospective mechanisms of herbs and spices: A compiled update. Heliyon, 12(1), Article e44306. https://doi.org/10.1016/j.heliyon.2025.e44306.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Segovia, F. J., Hidalgo, G. I., Villasante, J., Ramis, X., Almajano, M. P. (2018). Avocado seed: A comparative study of antioxidant content and capacity in protecting oil models from oxidation. Molecules, 23(10), Article 2421. https://doi.org/10.3390/molecules23102421.</mixed-citation><mixed-citation xml:lang="en">Segovia, F. J., Hidalgo, G. I., Villasante, J., Ramis, X., Almajano, M. P. (2018). Avocado seed: A comparative study of antioxidant content and capacity in protecting oil models from oxidation. Molecules, 23(10), Article 2421. https://doi.org/10.3390/molecules23102421.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bangar, S. P., Dunno, K., Dhull, S. B., Kumar-Siroha, A., Changan, S., Maqsood, S. et al. (2022). Avocado seed discoveries: Chemical composition, biological properties, and industrial food applications. Food Chemistry: X, 16, Article 100507. https://doi.org/10.1016/j.fochx.2022.100507.</mixed-citation><mixed-citation xml:lang="en">Bangar, S. P., Dunno, K., Dhull, S. B., Kumar-Siroha, A., Changan, S., Maqsood, S. et al. (2022). Avocado seed discoveries: Chemical composition, biological properties, and industrial food applications. Food Chemistry: X, 16, Article 100507. https://doi.org/10.1016/j.fochx.2022.100507.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J., Osioma, E., Metie, S. O., Igue, U. B., Isoje, E. F., Okom, S.U. (2023). Xylopiaa ethiopica HPLC-DAD polyphenol profiling and antioxidant status from South-South region of Nigeria. Ovidius University Annals of Chemistry, 34(2), 104–111. https://doi.org/10.2478/auoc-2023-0014.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J., Osioma, E., Metie, S. O., Igue, U. B., Isoje, E. F., Okom, S.U. (2023). Xylopiaa ethiopica HPLC-DAD polyphenol profiling and antioxidant status from South-South region of Nigeria. Ovidius University Annals of Chemistry, 34(2), 104–111. https://doi.org/10.2478/auoc-2023-0014.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J., Jacdonmi, O., Igue, U. B., Iyhe, P., Isoje, E. F., Okom, S. U. et al. (2023). Comparative study of polyphenol profile after stimulated post-intestinal digestion of raw and dried ginger leaves. Annals of Science and Technology, 8(2), 22–29. https://doi.org/10.2478/ast-2023-0012.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J., Jacdonmi, O., Igue, U. B., Iyhe, P., Isoje, E. F., Okom, S. U. et al. (2023). Comparative study of polyphenol profile after stimulated post-intestinal digestion of raw and dried ginger leaves. Annals of Science and Technology, 8(2), 22–29. https://doi.org/10.2478/ast-2023-0012.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Okom, S. U., Ojugbeli, E. T., Okpoghono, J., Onyesom, I. (2023). Safety and antimalarial therapeutic index of alkaloid-rich extract of Phyllanthus amarus Schumach. and Thonn. in mice. Heliyon, 9(12), Article e23078. https://doi.org/10.1016/j.heliyon.2023.e23078.</mixed-citation><mixed-citation xml:lang="en">Okom, S. U., Ojugbeli, E. T., Okpoghono, J., Onyesom, I. (2023). Safety and antimalarial therapeutic index of alkaloid-rich extract of Phyllanthus amarus Schumach. and Thonn. in mice. Heliyon, 9(12), Article e23078. https://doi.org/10.1016/j.heliyon.2023.e23078.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kupnik, K., Primožič, M., Kokol, V., Knez, Ž., Leitgeb, M. (2023). Enzymatic, antioxidant, and antimicrobial activities of bioactive compounds from avocado (Persea americana L.) seeds. Plants, 12(5), Article 1201. https://doi.org/10.3390/plants12051201.</mixed-citation><mixed-citation xml:lang="en">Kupnik, K., Primožič, M., Kokol, V., Knez, Ž., Leitgeb, M. (2023). Enzymatic, antioxidant, and antimicrobial activities of bioactive compounds from avocado (Persea americana L.) seeds. Plants, 12(5), Article 1201. https://doi.org/10.3390/plants12051201.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J., Ukperegbulem, J. K., Igue, U. B. (2024). Anti-lipidemic and protein restoration potential of Monodora myristica (Gaertn.) in rats fed with cassava containing crude oil. Food and Raw Materials, 12(2), 249–255. https://doi.org/10.21603/2308-4057-2024-2-602.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J., Ukperegbulem, J. K., Igue, U. B. (2024). Anti-lipidemic and protein restoration potential of Monodora myristica (Gaertn.) in rats fed with cassava containing crude oil. Food and Raw Materials, 12(2), 249–255. https://doi.org/10.21603/2308-4057-2024-2-602.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Okpoghono, J., Okonta, C.I., Omoike, G.O., Ekayoda, O., Okuchukwu, O., Onakurhefe, P. (2025). Antioxidant properties, phytochemicals and health benefit of ‘Red Delicious’ Malus domestica. Discover Food, 5, Ariticle 431. https://doi.org/10.1007/s44187-025-00724-9.</mixed-citation><mixed-citation xml:lang="en">Okpoghono, J., Okonta, C.I., Omoike, G.O., Ekayoda, O., Okuchukwu, O., Onakurhefe, P. (2025). Antioxidant properties, phytochemicals and health benefit of ‘Red Delicious’ Malus domestica. Discover Food, 5, Ariticle 431. https://doi.org/10.1007/s44187-025-00724-9.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">14. Samtiya, M., Acharya, S., Pandey, K. K., Aluko, R. E., Udenigwe, C. C., Dhewa, T. (2021). Production, purification, and potential health applications of edible seeds’ bioactive peptides: A concise review. Foods, 10(11), Article 2696. https://doi.org/10.3390/foods10112696.</mixed-citation><mixed-citation xml:lang="en">14. Samtiya, M., Acharya, S., Pandey, K. K., Aluko, R. E., Udenigwe, C. C., Dhewa, T. (2021). Production, purification, and potential health applications of edible seeds’ bioactive peptides: A concise review. Foods, 10(11), Article 2696. https://doi.org/10.3390/foods10112696.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Athaydes, B. R., Tosta, C., Carminati, R. Z., Kuster, R. M., Kitagawa, R. R., Gonçalves, R. de C. R. (2022). Avocado (Persea americana Mill.) seeds compounds affect Helicobacter pylori infection and gastric adenocarcinoma cells growth. Journal of Functional Foods, 99, Article 105352. https://doi.org/10.1016/j.jff.2022.105352.</mixed-citation><mixed-citation xml:lang="en">Athaydes, B. R., Tosta, C., Carminati, R. Z., Kuster, R. M., Kitagawa, R. R., Gonçalves, R. de C. R. (2022). Avocado (Persea americana Mill.) seeds compounds affect Helicobacter pylori infection and gastric adenocarcinoma cells growth. Journal of Functional Foods, 99, Article 105352. https://doi.org/10.1016/j.jff.2022.105352.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Setyawan, H. Y., Sukardi, S., Puriwangi, C. A. (August 25, 2021). Phytochemicals Properties of Avocado Seed: A Review. IOP Conference Series: Earth and Environmental Science International Conference on Green Agro-industry and Bioeconomy. Malang, Indonesia, 2021. https://doi.org/10.1088/1755-1315/733/1/012090.</mixed-citation><mixed-citation xml:lang="en">Setyawan, H. Y., Sukardi, S., Puriwangi, C. A. (August 25, 2021). Phytochemicals Properties of Avocado Seed: A Review. IOP Conference Series: Earth and Environmental Science International Conference on Green Agro-industry and Bioeconomy. Malang, Indonesia, 2021. https://doi.org/10.1088/1755-1315/733/1/012090.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Siol, M., Sadowska, A. (2023). Chemical composition, physicochemical and bioactive properties of avocado (Persea americana) seed and its potential use in functional food design. Agriculture, 13(2), Article 316. https://doi.org/10.3390/agriculture13020316.</mixed-citation><mixed-citation xml:lang="en">Siol, M., Sadowska, A. (2023). Chemical composition, physicochemical and bioactive properties of avocado (Persea americana) seed and its potential use in functional food design. Agriculture, 13(2), Article 316. https://doi.org/10.3390/agriculture13020316.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed, N., Smith, R. W., Henao, J. J. A., Stark, K. D., Spagnuolo, P. A. (2018). Analytical method to detect and quantify avocatin B in hass avocado seed and pulp matter. Journal of Natural Products, 81(4), 818–824. https://doi.org/10.1021/acs.jnatprod.7b00914.</mixed-citation><mixed-citation xml:lang="en">Ahmed, N., Smith, R. W., Henao, J. J. A., Stark, K. D., Spagnuolo, P. A. (2018). Analytical method to detect and quantify avocatin B in hass avocado seed and pulp matter. Journal of Natural Products, 81(4), 818–824. https://doi.org/10.1021/acs.jnatprod.7b00914.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Oluwagunwa, O. A., Alashi, A. M., Riedl, K., Aluko, R. E. (2024). Effect of chlorophyll content on the multifunctional properties of Telfairia occidentalis aqueous leaf polyphenolic concentrate. South African Journal of Botany, 174, 85–95. https://doi.org/10.1016/j.sajb.2024.08.058.</mixed-citation><mixed-citation xml:lang="en">Oluwagunwa, O. A., Alashi, A. M., Riedl, K., Aluko, R. E. (2024). Effect of chlorophyll content on the multifunctional properties of Telfairia occidentalis aqueous leaf polyphenolic concentrate. South African Journal of Botany, 174, 85–95. https://doi.org/10.1016/j.sajb.2024.08.058.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ali, A. I., Dandago, M. A., Ali, F. I. (2024). Food applications of Telfairia occidentalis as a functional ingredient and nanoencapsulation as a promising approach toward enhancing food fortification. Chapter in a book: Phytochemicals in Agriculture and Food. InTechOpen, 2024. https://doi.org/10.5772/intechopen.111716.</mixed-citation><mixed-citation xml:lang="en">Ali, A. I., Dandago, M. A., Ali, F. I. (2024). Food applications of Telfairia occidentalis as a functional ingredient and nanoencapsulation as a promising approach toward enhancing food fortification. Chapter in a book: Phytochemicals in Agriculture and Food. InTechOpen, 2024. https://doi.org/10.5772/intechopen.111716.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Osukoya, O. A., Adegbenro, D., Onikanni, S. A., Ojo, O. A., Onasanya, A. (2016). Antinociceptive and antioxidant activities of the methanolic extract of Telfairia occidentalis seeds. Ancient Science of Life, 36, 98–103. https://doi.org/10.4103/asl.ASL_142_16.</mixed-citation><mixed-citation xml:lang="en">Osukoya, O. A., Adegbenro, D., Onikanni, S. A., Ojo, O. A., Onasanya, A. (2016). Antinociceptive and antioxidant activities of the methanolic extract of Telfairia occidentalis seeds. Ancient Science of Life, 36, 98–103. https://doi.org/10.4103/asl.ASL_142_16.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ifesan, B. O. T., Olorunsola, B. O., Ifesan, B.T. (2015). Nutritional composition and acceptability of candy from avocado seed (Persea americana). International Journal of Agriculture Innovations and Research, 3(6), 1631–1634.</mixed-citation><mixed-citation xml:lang="en">Ifesan, B. O. T., Olorunsola, B. O., Ifesan, B.T. (2015). Nutritional composition and acceptability of candy from avocado seed (Persea americana). International Journal of Agriculture Innovations and Research, 3(6), 1631–1634.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Omorevbarhia, O., Umerie, S. C., Aniefuna, E. L., Enoch, O. C. (2023). Proximate, phytochemical and mineral composition of methanol extract of persea americana seed. International Journal of Biochemistry Research and Review, 32(2), 1–9. https://doi.org/10.9734/ijbcrr/2023/v32i2797.</mixed-citation><mixed-citation xml:lang="en">Omorevbarhia, O., Umerie, S. C., Aniefuna, E. L., Enoch, O. C. (2023). Proximate, phytochemical and mineral composition of methanol extract of persea americana seed. International Journal of Biochemistry Research and Review, 32(2), 1–9. https://doi.org/10.9734/ijbcrr/2023/v32i2797.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Báez-Magaña, M., Ochoa-Zarzosa, A., Alva-Murillo, N., Salgado-Garciglia, R., López-Meza, J. E. (2019). Lipid-rich extract from Mexican avocado seed (Persea americana var. drymifolia) reduces staphylococcus aureus internalization and regulates innate immune response in bovine mammary epithelial cells. Journal of Immunology Research, 2019, Article 7083491. https://doi.org/10.1155/2019/7083491.</mixed-citation><mixed-citation xml:lang="en">Báez-Magaña, M., Ochoa-Zarzosa, A., Alva-Murillo, N., Salgado-Garciglia, R., López-Meza, J. E. (2019). Lipid-rich extract from Mexican avocado seed (Persea americana var. drymifolia) reduces staphylococcus aureus internalization and regulates innate immune response in bovine mammary epithelial cells. Journal of Immunology Research, 2019, Article 7083491. https://doi.org/10.1155/2019/7083491.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Okorie, N. H., Omorevbarhia, O., Umerie, S. C., Aniefuna, E. L., Ujam, N. T., Ali, I. J. (2024). Proximate, phytochemical, mineral composition and antioxidant effects of methanol extract of Persea americana (avacado pear) seed. Fudma Journal of Sciences, 8(3), 166–174. https://doi.org/10.33003/fjs-2024-0803-2303.</mixed-citation><mixed-citation xml:lang="en">Okorie, N. H., Omorevbarhia, O., Umerie, S. C., Aniefuna, E. L., Ujam, N. T., Ali, I. J. (2024). Proximate, phytochemical, mineral composition and antioxidant effects of methanol extract of Persea americana (avacado pear) seed. Fudma Journal of Sciences, 8(3), 166–174. https://doi.org/10.33003/fjs-2024-0803-2303.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Egbuonu, A. C. C., Opara, I. C., Onyeabo, C., Uchenna, N. O. (2018). Proximate, functional, antinutrient and antimicrobial properties of avocado pear (Persea americana) seeds. Journal of Nutritional Health and Food Engineering, 8(1), 78–82. https://doi.org/10.15406/jnhfe.2018.08.00260.</mixed-citation><mixed-citation xml:lang="en">Egbuonu, A. C. C., Opara, I. C., Onyeabo, C., Uchenna, N. O. (2018). Proximate, functional, antinutrient and antimicrobial properties of avocado pear (Persea americana) seeds. Journal of Nutritional Health and Food Engineering, 8(1), 78–82. https://doi.org/10.15406/jnhfe.2018.08.00260.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mahawan, M. A., Francia, M., Tenorio, N., Gomez, J. A., Bronce, R. A. (2015). Characterization of flour from avocado seed kernel. Asia Pacific Journal of Multidisciplinary Research, 3(4), 34–40.</mixed-citation><mixed-citation xml:lang="en">Mahawan, M. A., Francia, M., Tenorio, N., Gomez, J. A., Bronce, R. A. (2015). Characterization of flour from avocado seed kernel. Asia Pacific Journal of Multidisciplinary Research, 3(4), 34–40.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ejiofor, N. C., Ezeagu, I. E., Ayoola, M. B., Umera, E. A. (2018). Determination of the chemical composition of avocado (Persea Americana) seed. Advances in Food Technology and Nutritional Sciences — Open Journal, SE(2), S51-S55. https://doi.org/10.17140/aftnsoj-se-2-107.</mixed-citation><mixed-citation xml:lang="en">Ejiofor, N. C., Ezeagu, I. E., Ayoola, M. B., Umera, E. A. (2018). Determination of the chemical composition of avocado (Persea Americana) seed. Advances in Food Technology and Nutritional Sciences — Open Journal, SE(2), S51-S55. https://doi.org/10.17140/aftnsoj-se-2-107.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Arukwe, U., Amadi, B. A., Duru, M. K. C., Agomuo, E. N., Adindu, E. A., Odika, P. C. et al. (2012). Chemical composition of Persea americana leaf, fruit and seed. International Journal of Research and Reviews in Applied Sciences, 11(2), 346–349.</mixed-citation><mixed-citation xml:lang="en">Arukwe, U., Amadi, B. A., Duru, M. K. C., Agomuo, E. N., Adindu, E. A., Odika, P. C. et al. (2012). Chemical composition of Persea americana leaf, fruit and seed. International Journal of Research and Reviews in Applied Sciences, 11(2), 346–349.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Office of the Assistant Secretary for Health (OASH). Nutritional goals for each age/sex group used in assessing adequacy of USDA Food Patterns at various calorie levels. National Archives. Retrieved from https://odphp.health.gov/sites/default/files/2019-09/Appendix-E3-1-Table-A4.pdf Accessed August 29, 2025.</mixed-citation><mixed-citation xml:lang="en">Office of the Assistant Secretary for Health (OASH). Nutritional goals for each age/sex group used in assessing adequacy of USDA Food Patterns at various calorie levels. National Archives. Retrieved from https://odphp.health.gov/sites/default/files/2019-09/Appendix-E3-1-Table-A4.pdf Accessed August 29, 2025.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kulczyński, B., Kobus-Cisowska, J., Taczanowski, M., Kmiecik, D., Gramza-Michałowska, A. (2019). The chemical composition and nutritional value of chia seeds-current state of knowledge. Nutrients, 11(6), Article 1242. https://doi.org/10.3390/nu11061242.</mixed-citation><mixed-citation xml:lang="en">Kulczyński, B., Kobus-Cisowska, J., Taczanowski, M., Kmiecik, D., Gramza-Michałowska, A. (2019). The chemical composition and nutritional value of chia seeds-current state of knowledge. Nutrients, 11(6), Article 1242. https://doi.org/10.3390/nu11061242.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Biswas, S., Islam, F., Imran, A., Zahoor, T., Noreen, R., Fatima, M. et al. (2023). Phytochemical profile, nutritional composition, and therapeutic potentials of chia seeds: A concise review. Cogent Food and Agriculture, 9(1), Article 2220516. https://doi.org/10.1080/23311932.2023.2220516.</mixed-citation><mixed-citation xml:lang="en">Biswas, S., Islam, F., Imran, A., Zahoor, T., Noreen, R., Fatima, M. et al. (2023). Phytochemical profile, nutritional composition, and therapeutic potentials of chia seeds: A concise review. Cogent Food and Agriculture, 9(1), Article 2220516. https://doi.org/10.1080/23311932.2023.2220516.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Asad, M., Malik, A. (2024). Almond varieties: Nutritional and chemical composition and health benefits and culinary application. Chapter in a book: Nut Consumption and its Usefulness in the Modern World. IntechOpen, 2024. https://doi.org/10.5772/intechopen.1005139.</mixed-citation><mixed-citation xml:lang="en">Asad, M., Malik, A. (2024). Almond varieties: Nutritional and chemical composition and health benefits and culinary application. Chapter in a book: Nut Consumption and its Usefulness in the Modern World. IntechOpen, 2024. https://doi.org/10.5772/intechopen.1005139.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Barreca, D., Nabavi, S. M., Sureda, A., Rasekhian, M., Raciti, R., Silva, A. S. et al. (2020). Almonds (Prunus Dulcis Mill. D. A. Webb): A Source of Nutrients and Health-Promoting Compounds. Nutrients, 12(3), Article 672. https://doi.org/10.3390/nu12030672.</mixed-citation><mixed-citation xml:lang="en">Barreca, D., Nabavi, S. M., Sureda, A., Rasekhian, M., Raciti, R., Silva, A. S. et al. (2020). Almonds (Prunus Dulcis Mill. D. A. Webb): A Source of Nutrients and Health-Promoting Compounds. Nutrients, 12(3), Article 672. https://doi.org/10.3390/nu12030672.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jimenez, P., Garcia, P., Quitral, V., Vasquez, K., Parra-Ruiz, C., Reyes-Farias, M. et al. (2020). Pulp, leaf, peel and seed of avocado fruit: A review of bioactive compounds and healthy benefits. Food Reviews International, 37(6), 619–655. https://doi.org/10.1080/87559129.2020.1717520.</mixed-citation><mixed-citation xml:lang="en">Jimenez, P., Garcia, P., Quitral, V., Vasquez, K., Parra-Ruiz, C., Reyes-Farias, M. et al. (2020). Pulp, leaf, peel and seed of avocado fruit: A review of bioactive compounds and healthy benefits. Food Reviews International, 37(6), 619–655. https://doi.org/10.1080/87559129.2020.1717520.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang, K., Dong, R., Hu, X., Ren, C., Li, Y. (2021). Oat-based foods: Chemical constituents, glycemic index, and the effect of processing. Foods, 10(6), Article 1304. https://doi.org/10.3390/foods10061304.</mixed-citation><mixed-citation xml:lang="en">Zhang, K., Dong, R., Hu, X., Ren, C., Li, Y. (2021). Oat-based foods: Chemical constituents, glycemic index, and the effect of processing. Foods, 10(6), Article 1304. https://doi.org/10.3390/foods10061304.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bahru, T. B., Tadele, Z. H., Ajebe, E.G. (2019). A review on avocado seed: Functionality, composition, antioxidant and antimicrobial properties. International Journal of Chemical Sciences, 27(2), 1–10. https://doi.org/10.9734/CSJI/2019/v27i230112.</mixed-citation><mixed-citation xml:lang="en">Bahru, T. B., Tadele, Z. H., Ajebe, E.G. (2019). A review on avocado seed: Functionality, composition, antioxidant and antimicrobial properties. International Journal of Chemical Sciences, 27(2), 1–10. https://doi.org/10.9734/CSJI/2019/v27i230112.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Asiwe, E. S., Igwe, C. U., Iheanacho, K. M. E., Onyeocha, I. O., Onwuliri. V. A. (2021). Bioactive composition and acute oral toxicity studies on Persea Americana seed ethyl acetate fraction. Asian Journal of Research in Biochemistry, 8(4), 10–17. https://doi.org/10.9734/ajrb/2021/v8i430186.</mixed-citation><mixed-citation xml:lang="en">Asiwe, E. S., Igwe, C. U., Iheanacho, K. M. E., Onyeocha, I. O., Onwuliri. V. A. (2021). Bioactive composition and acute oral toxicity studies on Persea Americana seed ethyl acetate fraction. Asian Journal of Research in Biochemistry, 8(4), 10–17. https://doi.org/10.9734/ajrb/2021/v8i430186.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Achu, M. B. M., Djuikwo, R. V., Tamo, S. G., Fotso, C. L. M., Fowe, M. C. D., Fokou, E. (2021). Physical characteristics and the effect of boiling and fermentation on the nutritional value of Telfairia occidentalis seeds. Journal of Agricultural Chemistry and Environment, 10(4), 389–401. https://doi.org/10.4236/jacen.2021.104025.</mixed-citation><mixed-citation xml:lang="en">Achu, M. B. M., Djuikwo, R. V., Tamo, S. G., Fotso, C. L. M., Fowe, M. C. D., Fokou, E. (2021). Physical characteristics and the effect of boiling and fermentation on the nutritional value of Telfairia occidentalis seeds. Journal of Agricultural Chemistry and Environment, 10(4), 389–401. https://doi.org/10.4236/jacen.2021.104025.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Miteu, G. D., Ezeh, B. C. (2022). Effects of roasting periods on the nutritive value of telfaira occidentalis (Fluted Pumpkin) seeds. IPS Journal of Nutrition and Food Science, 1(1), 6–10. https://doi.org/10.54117/ijnfs.v1i1.2.</mixed-citation><mixed-citation xml:lang="en">Miteu, G. D., Ezeh, B. C. (2022). Effects of roasting periods on the nutritive value of telfaira occidentalis (Fluted Pumpkin) seeds. IPS Journal of Nutrition and Food Science, 1(1), 6–10. https://doi.org/10.54117/ijnfs.v1i1.2.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Ouattara, N., Digbeu, Y. D., Koffi, Y. G., Due, A. (2022). Nutritional potentiality and antinutritional properties of Telfairia occidentalis from Côte d’lvoire. GSC Biological and Pharmaceutical Sciences, 18(02), 338–343. https://doi.org/10.30574/gscbps.2022.18.2.0073</mixed-citation><mixed-citation xml:lang="en">Ouattara, N., Digbeu, Y. D., Koffi, Y. G., Due, A. (2022). Nutritional potentiality and antinutritional properties of Telfairia occidentalis from Côte d’lvoire. GSC Biological and Pharmaceutical Sciences, 18(02), 338–343. https://doi.org/10.30574/gscbps.2022.18.2.0073</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Chuku, L. C., Chinaka, N. C. (2021). Proximate and phytochemical compositions of dried seeds of fluted pumpkin (Telfairia occidentalis). Journal of Complementary and Alternative Medical Research,13(1), 14–19. https://doi.org/10.9734/JOCAMR/2021/v13i130215.</mixed-citation><mixed-citation xml:lang="en">Chuku, L. C., Chinaka, N. C. (2021). Proximate and phytochemical compositions of dried seeds of fluted pumpkin (Telfairia occidentalis). Journal of Complementary and Alternative Medical Research,13(1), 14–19. https://doi.org/10.9734/JOCAMR/2021/v13i130215.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Nzeagwu, O. C. Amadi, A. U. (2020). Effect of processing on chemical composition of fluted pumpkin (Telfairia occidentalis) seed flour and sensory evaluation of soup produced from the flour. Nigerian Journal of Nutritional Sciences, 41(1), 132–140.</mixed-citation><mixed-citation xml:lang="en">Nzeagwu, O. C. Amadi, A. U. (2020). Effect of processing on chemical composition of fluted pumpkin (Telfairia occidentalis) seed flour and sensory evaluation of soup produced from the flour. Nigerian Journal of Nutritional Sciences, 41(1), 132–140.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Eseyin, O. A., Sattar, M. A., Rathore, H. A. (2014). A Review of the pharmacological and biological activities of the aerial parts of Telfairia occidentalis Hook. f. (Cucurbitaceae). Tropical Journal of Pharmaceutical Research. 13(10), 1761–1769. https://doi.org/10.4314/tjpr.v13i10.28.</mixed-citation><mixed-citation xml:lang="en">Eseyin, O. A., Sattar, M. A., Rathore, H. A. (2014). A Review of the pharmacological and biological activities of the aerial parts of Telfairia occidentalis Hook. f. (Cucurbitaceae). Tropical Journal of Pharmaceutical Research. 13(10), 1761–1769. https://doi.org/10.4314/tjpr.v13i10.28.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Batool, M., Ranjha, M. M. A. N., Roobab, U., Manzoor, M. F., Farooq, U., Nadeem, H. R. et al. (2022). Nutritional value, phytochemical potential, and therapeutic benefits of pumpkin (Cucurbita sp.). Plants, 11(11), Article 1394. https://doi.org/10.3390/plants11111394.</mixed-citation><mixed-citation xml:lang="en">Batool, M., Ranjha, M. M. A. N., Roobab, U., Manzoor, M. F., Farooq, U., Nadeem, H. R. et al. (2022). Nutritional value, phytochemical potential, and therapeutic benefits of pumpkin (Cucurbita sp.). Plants, 11(11), Article 1394. https://doi.org/10.3390/plants11111394.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Singh, A., Kumar, V. (2024). Pumpkin seeds as nutraceutical and functional food ingredient for future: A review. Grain and Oil Science and Technology, 7(1), 12–29. https://doi.org/10.1016/j.gaost.2023.12.002.</mixed-citation><mixed-citation xml:lang="en">Singh, A., Kumar, V. (2024). Pumpkin seeds as nutraceutical and functional food ingredient for future: A review. Grain and Oil Science and Technology, 7(1), 12–29. https://doi.org/10.1016/j.gaost.2023.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Petraru, A., Ursachi, F., Amariei, S. (2021). Nutritional characteristics assessment of sunflower seeds, oil and cake. perspective of using sunflower oilcakes as a functional ingredient. Plants, 10(11), Article 2487. https://doi.org/10.3390/plants10112487.</mixed-citation><mixed-citation xml:lang="en">Petraru, A., Ursachi, F., Amariei, S. (2021). Nutritional characteristics assessment of sunflower seeds, oil and cake. perspective of using sunflower oilcakes as a functional ingredient. Plants, 10(11), Article 2487. https://doi.org/10.3390/plants10112487.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Aanchal. (2023). Nutritional and health benefits of soybean and soybean developed food. The Pharma Innovation Journal, 12(6), 4991–4999.</mixed-citation><mixed-citation xml:lang="en">Aanchal. (2023). Nutritional and health benefits of soybean and soybean developed food. The Pharma Innovation Journal, 12(6), 4991–4999.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Singh, P., Pandey, V. K., Sultan, Z., Singh, R., Dar, A. H. (2023). Classification, benefits, and applications of various anti-nutritional factors present in edible crops. Journal of Agriculture and Food Research, 14, Article 100902. https://doi.org/10.1016/j.jafr.2023.100902.</mixed-citation><mixed-citation xml:lang="en">Singh, P., Pandey, V. K., Sultan, Z., Singh, R., Dar, A. H. (2023). Classification, benefits, and applications of various anti-nutritional factors present in edible crops. Journal of Agriculture and Food Research, 14, Article 100902. https://doi.org/10.1016/j.jafr.2023.100902.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Samtiya, M., Aluko, R. E. Dhewa, T. (2020). Plant food anti-nutritional factors and their reduction strategies: An overview. Food Production, Processing and Nutrition, 2, Article 6. https://doi.org/10.1186/s43014-020-0020-5.</mixed-citation><mixed-citation xml:lang="en">Samtiya, M., Aluko, R. E. Dhewa, T. (2020). Plant food anti-nutritional factors and their reduction strategies: An overview. Food Production, Processing and Nutrition, 2, Article 6. https://doi.org/10.1186/s43014-020-0020-5.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Salim, R., Nehvi, I. B., Mir, R. A., Tyagi, A., Ali, S., Bhat, O. M. (2023). A review on anti-nutritional factors: Unraveling the natural gateways to human health. Frontiers in Nutrition, 10, Article 1215873. https://doi.org/10.3389/fnut.2023.1215873.</mixed-citation><mixed-citation xml:lang="en">Salim, R., Nehvi, I. B., Mir, R. A., Tyagi, A., Ali, S., Bhat, O. M. (2023). A review on anti-nutritional factors: Unraveling the natural gateways to human health. Frontiers in Nutrition, 10, Article 1215873. https://doi.org/10.3389/fnut.2023.1215873.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed, O. M., Fahim, H. I., Mohamed, E. E., Abdel-Moneim, A. (2022). Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities. Environmental Science and Pollution Research International, 29(29), 43858–43873. https://doi.org/10.1007/s11356-022-18902-y.</mixed-citation><mixed-citation xml:lang="en">Ahmed, O. M., Fahim, H. I., Mohamed, E. E., Abdel-Moneim, A. (2022). Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities. Environmental Science and Pollution Research International, 29(29), 43858–43873. https://doi.org/10.1007/s11356-022-18902-y.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Marra, A., Manousakis, V., Zervas, G. P., Koutis, N., Finos, M. A., Adamantidi, T. et al. (2024). Avocado and its by-products as natural sources of valuable anti-inflammatory and antioxidant bioactives for functional foods and cosmetics with health-promoting properties. Applied Sciences, 14(14), Article 5978. https://doi.org/10.3390/app14145978.</mixed-citation><mixed-citation xml:lang="en">Marra, A., Manousakis, V., Zervas, G. P., Koutis, N., Finos, M. A., Adamantidi, T. et al. (2024). Avocado and its by-products as natural sources of valuable anti-inflammatory and antioxidant bioactives for functional foods and cosmetics with health-promoting properties. Applied Sciences, 14(14), Article 5978. https://doi.org/10.3390/app14145978.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Osukoya, O. A., Oyinloye, B. E., Ajiboye, B. O., Olokode, K. A., Adeola, H. A. (2021). Nephroprotective and anti-inflammatory potential of aqueous extract from Persea americana seeds against cadmium-induced nephrotoxicity in Wistar rats. Biometals, 34(5), 1141–1153. https://doi.org/10.1007/s10534-021-00333-w.</mixed-citation><mixed-citation xml:lang="en">Osukoya, O. A., Oyinloye, B. E., Ajiboye, B. O., Olokode, K. A., Adeola, H. A. (2021). Nephroprotective and anti-inflammatory potential of aqueous extract from Persea americana seeds against cadmium-induced nephrotoxicity in Wistar rats. Biometals, 34(5), 1141–1153. https://doi.org/10.1007/s10534-021-00333-w.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Alkhalaf, M. I., Alansari, W. S., Ibrahim, E. A., Elhalwagy, M. E. (2018). Anti-oxidant, anti-inflammatory and anti-cancer activities of avocado (Persea americana) fruit and seed extract. Journal of King Saud University — Science, 31(4), 1358–1362. https://doi.org/10.1016/j.jksus.2018.10.010.</mixed-citation><mixed-citation xml:lang="en">Alkhalaf, M. I., Alansari, W. S., Ibrahim, E. A., Elhalwagy, M. E. (2018). Anti-oxidant, anti-inflammatory and anti-cancer activities of avocado (Persea americana) fruit and seed extract. Journal of King Saud University — Science, 31(4), 1358–1362. https://doi.org/10.1016/j.jksus.2018.10.010.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Dabas, D., Elias, R. J., Ziegler, G. R., Lambert, J. D. (2019). In vitro antioxidant and cancer inhibitory activity of a colored avocado seed extract. International Journal of Food Science, 2019, Article 6509421. https://doi.org/10.1155/2019/6509421.</mixed-citation><mixed-citation xml:lang="en">Dabas, D., Elias, R. J., Ziegler, G. R., Lambert, J. D. (2019). In vitro antioxidant and cancer inhibitory activity of a colored avocado seed extract. International Journal of Food Science, 2019, Article 6509421. https://doi.org/10.1155/2019/6509421.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Ojo, O. A., Amanze, J. C., Oni, A. I., Grant, S., Iyobhebhe, M., Elebiyo, T. C. et al. (2022). Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway. Scientific Reports, 12(1), Article 2919. https://doi.org/10.1038/s41598-022-07015-8.</mixed-citation><mixed-citation xml:lang="en">Ojo, O. A., Amanze, J. C., Oni, A. I., Grant, S., Iyobhebhe, M., Elebiyo, T. C. et al. (2022). Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway. Scientific Reports, 12(1), Article 2919. https://doi.org/10.1038/s41598-022-07015-8.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Makasa, Y., (2024). Evaluation of the ameliorative effects of Persea americana seeds on the biochemical and hematological parameters in type 2 diabetic rats. Journal of Clinical and Biomedical Sciences, 14(3), 105–114. https://doi.org/10.58739/jcbs/v14i3.109.</mixed-citation><mixed-citation xml:lang="en">Makasa, Y., (2024). Evaluation of the ameliorative effects of Persea americana seeds on the biochemical and hematological parameters in type 2 diabetic rats. Journal of Clinical and Biomedical Sciences, 14(3), 105–114. https://doi.org/10.58739/jcbs/v14i3.109.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Ogbonnaya, E. A., Belonwu, D. C., Ezim, O. E., Umeh, U. (2024). Ameliorative potentials of Persea americana Mill (Avocado) seed extract on acetaminopheninduced hepatic insufficiency in rats. Asian Journal of Research in Biochemistry, 14(2), 28–39. https://doi.org/10.9734/ajrb/2024/v14i2281.</mixed-citation><mixed-citation xml:lang="en">Ogbonnaya, E. A., Belonwu, D. C., Ezim, O. E., Umeh, U. (2024). Ameliorative potentials of Persea americana Mill (Avocado) seed extract on acetaminopheninduced hepatic insufficiency in rats. Asian Journal of Research in Biochemistry, 14(2), 28–39. https://doi.org/10.9734/ajrb/2024/v14i2281.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Mokhele, S., Aboyade, O., Katerere, D. R. (2024). Obesity prevention effects of avocado (Persea americana) seed powder in high-fat diet-induced obesity in rats. Nutraceuticals, 4(3), 417–429. https://doi.org/10.3390/nutraceuticals4030025.</mixed-citation><mixed-citation xml:lang="en">Mokhele, S., Aboyade, O., Katerere, D. R. (2024). Obesity prevention effects of avocado (Persea americana) seed powder in high-fat diet-induced obesity in rats. Nutraceuticals, 4(3), 417–429. https://doi.org/10.3390/nutraceuticals4030025.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">García-Berumen, C. I., Vargas-Vargas, M. A., Ortiz-Avila, O., Piña-Zentella, R. M., Ramos-Gómez, M., Figueroa-García, M. del C. et al (2022). Avocado oil alleviates non-alcoholic fatty liver disease by improving mitochondrial function, oxidative stress and inflammation in rats fed a high fat-High fructose diet. Frontiers in Pharmacology, 13, Article 1089130. https://doi.org/10.3389/fphar.2022.1089130.</mixed-citation><mixed-citation xml:lang="en">García-Berumen, C. I., Vargas-Vargas, M. A., Ortiz-Avila, O., Piña-Zentella, R. M., Ramos-Gómez, M., Figueroa-García, M. del C. et al (2022). Avocado oil alleviates non-alcoholic fatty liver disease by improving mitochondrial function, oxidative stress and inflammation in rats fed a high fat-High fructose diet. Frontiers in Pharmacology, 13, Article 1089130. https://doi.org/10.3389/fphar.2022.1089130.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez-Quezada, V., Velázquez-Guadarrama, N., Mendoza-Elizalde, S., Hernández-Iturriaga, M., Landaverde, P. V., Loarca-Piña, G. (2024). Bioaccessibility of bioactive compounds present in Persea americana Mill. seed ingredient during oralgastric digestion with antibacterial capacity against Helicobacter pylori. Journal of Ethnopharmacology, 331, Article 118259. https://doi.org/10.1016/j.jep.2024.118259.</mixed-citation><mixed-citation xml:lang="en">Sánchez-Quezada, V., Velázquez-Guadarrama, N., Mendoza-Elizalde, S., Hernández-Iturriaga, M., Landaverde, P. V., Loarca-Piña, G. (2024). Bioaccessibility of bioactive compounds present in Persea americana Mill. seed ingredient during oralgastric digestion with antibacterial capacity against Helicobacter pylori. Journal of Ethnopharmacology, 331, Article 118259. https://doi.org/10.1016/j.jep.2024.118259.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Falodun, A., Erharuyi, O., Imieje, V., Ahomafor, J., Akunyuli, C., Jacobs, M. et al. (2014). In vitro evaluation of aliphatic fatty alcohol metabolites of Persea americana seed as potential antimalarial and antimicrobial agents. Nigerian Journal of Biotechnology, 27, 1–7.</mixed-citation><mixed-citation xml:lang="en">Falodun, A., Erharuyi, O., Imieje, V., Ahomafor, J., Akunyuli, C., Jacobs, M. et al. (2014). In vitro evaluation of aliphatic fatty alcohol metabolites of Persea americana seed as potential antimalarial and antimicrobial agents. Nigerian Journal of Biotechnology, 27, 1–7.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Jiménez-Arellanes, A., Luna-Herrera, J., Ruiz-Nicolás, R., Cornejo-Garrido, J., Tapia, A., Yépez-Mulia, L. (2013). Antiprotozoal and antimycobacterial activities of Persea americana seeds. BMC Complementary and Alternative Medicine, 13(1), Article 109. https://doi.org/10.1186/1472-6882-13-109.</mixed-citation><mixed-citation xml:lang="en">Jiménez-Arellanes, A., Luna-Herrera, J., Ruiz-Nicolás, R., Cornejo-Garrido, J., Tapia, A., Yépez-Mulia, L. (2013). Antiprotozoal and antimycobacterial activities of Persea americana seeds. BMC Complementary and Alternative Medicine, 13(1), Article 109. https://doi.org/10.1186/1472-6882-13-109.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Oboh, G., Odubanjo, V. O., Bello, F., Ademosun, A. O., Oyeleye, S. I., Nwanna, E. E. (2016). Aqueous extracts of avocado pear (Persea americana Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro. Journal of Basic and Clinical Physiology and Pharmacology, 27(2), 131–140. https://doi.org/10.1515/jbcpp-2015-0049.</mixed-citation><mixed-citation xml:lang="en">Oboh, G., Odubanjo, V. O., Bello, F., Ademosun, A. O., Oyeleye, S. I., Nwanna, E. E. (2016). Aqueous extracts of avocado pear (Persea americana Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro. Journal of Basic and Clinical Physiology and Pharmacology, 27(2), 131–140. https://doi.org/10.1515/jbcpp-2015-0049.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Agada, S. A., Odama, R. I., Kenechukwu, C. O., Aondoaseer, K., Ezeh, C. O., Uti, D. E. et al. (2024). Antioxidant and hepatoprotective effects of methanolic seed extract of Telfairia occidentalis on carbon tetrachloride induced hepatic damage in Wistar rats. Discover Medicine, 1, Article 75. https://doi.org/10.1007/s44337-024-00096-6.</mixed-citation><mixed-citation xml:lang="en">Agada, S. A., Odama, R. I., Kenechukwu, C. O., Aondoaseer, K., Ezeh, C. O., Uti, D. E. et al. (2024). Antioxidant and hepatoprotective effects of methanolic seed extract of Telfairia occidentalis on carbon tetrachloride induced hepatic damage in Wistar rats. Discover Medicine, 1, Article 75. https://doi.org/10.1007/s44337-024-00096-6.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Onuoha, N., Iroegbu, L. U., Ejike, C. E. (2017). Anti-diabetic properties of the seeds of fluted pumpkin (Telfairia occidentalis Hook f.) in a rat model of alloxaninduced diabetes mellitus. Biokemistri, 87–93.</mixed-citation><mixed-citation xml:lang="en">Onuoha, N., Iroegbu, L. U., Ejike, C. E. (2017). Anti-diabetic properties of the seeds of fluted pumpkin (Telfairia occidentalis Hook f.) in a rat model of alloxaninduced diabetes mellitus. Biokemistri, 87–93.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Olasehinde, O. R., Acho, M. A., Afolabi, O. B., Arise, R. O. (2023). Peptide hydrolysate of Telfairia occidentalis Hook f. seed protein promotes effective glucose homeostasis by improving β-cell dysfunction and abating carbohydrate metabolic disturbance in diabetic rats. Journal of Food Biochemistry, 2023, Article 6652466. https://doi.org/10.1155/2023/6652466.</mixed-citation><mixed-citation xml:lang="en">Olasehinde, O. R., Acho, M. A., Afolabi, O. B., Arise, R. O. (2023). Peptide hydrolysate of Telfairia occidentalis Hook f. seed protein promotes effective glucose homeostasis by improving β-cell dysfunction and abating carbohydrate metabolic disturbance in diabetic rats. Journal of Food Biochemistry, 2023, Article 6652466. https://doi.org/10.1155/2023/6652466.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Agu, F. U., Kalu, A. K., Akunneh-Wariso, C., Chinedu, I. B., Dimgba, U. C. (2023). Evaluation of the anti-diabetic potential of methanol seed extract of Telfairia occidentalis. GSC Biological and Pharmaceutical Sciences, 24(03), 274–278. https://doi.org/10.30574/gscbps.2023.24.3.0349.</mixed-citation><mixed-citation xml:lang="en">Agu, F. U., Kalu, A. K., Akunneh-Wariso, C., Chinedu, I. B., Dimgba, U. C. (2023). Evaluation of the anti-diabetic potential of methanol seed extract of Telfairia occidentalis. GSC Biological and Pharmaceutical Sciences, 24(03), 274–278. https://doi.org/10.30574/gscbps.2023.24.3.0349.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Onuegbu, A. J., Olisekodiaka, J. M, Ude, T., Amah, U. K., Okwara, J. E., Ifeadike, C. et al. (2015). Effects of Telfairia occidentalis seeds on the serum lipid profile and atherogenic indices of male albino wistar rats. Pakistan Journal of Nutrition, 14(9), 557–562. https://doi.org/10.3923/pjn.2015.557.562.</mixed-citation><mixed-citation xml:lang="en">Onuegbu, A. J., Olisekodiaka, J. M, Ude, T., Amah, U. K., Okwara, J. E., Ifeadike, C. et al. (2015). Effects of Telfairia occidentalis seeds on the serum lipid profile and atherogenic indices of male albino wistar rats. Pakistan Journal of Nutrition, 14(9), 557–562. https://doi.org/10.3923/pjn.2015.557.562.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Daramola, O. O., Oyeyemi, W. A., Onyendilefu, G. (2016). Effects of methanol extract of Telfairia occidentalis seed on serum lipid profile, biochemical and antioxidant activity in female Wistar rats. European Journal of Medicinal Plants, 15(2), 1–8. https://doi.org/10.9734/EJMP/2016/26723.</mixed-citation><mixed-citation xml:lang="en">Daramola, O. O., Oyeyemi, W. A., Onyendilefu, G. (2016). Effects of methanol extract of Telfairia occidentalis seed on serum lipid profile, biochemical and antioxidant activity in female Wistar rats. European Journal of Medicinal Plants, 15(2), 1–8. https://doi.org/10.9734/EJMP/2016/26723.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Okokon, J. E., Farooq, A. D., Choudhary, M. I., Antia, B. S. (2012). Immunomodulatory, anticancer and anti-inflammatory activities of telfairia occidentalis seed extract and fractions. International Journal of Food Nutrition and Safety, 2(2), 72–85.</mixed-citation><mixed-citation xml:lang="en">Okokon, J. E., Farooq, A. D., Choudhary, M. I., Antia, B. S. (2012). Immunomodulatory, anticancer and anti-inflammatory activities of telfairia occidentalis seed extract and fractions. International Journal of Food Nutrition and Safety, 2(2), 72–85.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Njoku, R. -C. C., Abarikwu, S. O. (2021). Antifertility and profertility effects of the leaves and seeds of fluted pumpkin: Sperm quality, hormonal effects and histomorphological changes in the testes of experimental animal models. Journal of Integrative Medicine, 19(2), 104–110. https://doi.org/10.1016/j.joim.2021.01.007.</mixed-citation><mixed-citation xml:lang="en">Njoku, R. -C. C., Abarikwu, S. O. (2021). Antifertility and profertility effects of the leaves and seeds of fluted pumpkin: Sperm quality, hormonal effects and histomorphological changes in the testes of experimental animal models. Journal of Integrative Medicine, 19(2), 104–110. https://doi.org/10.1016/j.joim.2021.01.007.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Njoku, R. -C. C., Abarikwu, S. O., Uwakwe, A. A., Mgbudom-Okah, C. J. (2018). Telfairia occidentalis -supplemented diet induces changes in sperm parameters and testosterone level in rats. Andrologia, 50(7), Article e13044. https://doi.org/10.1111/and.13044.</mixed-citation><mixed-citation xml:lang="en">Njoku, R. -C. C., Abarikwu, S. O., Uwakwe, A. A., Mgbudom-Okah, C. J. (2018). Telfairia occidentalis -supplemented diet induces changes in sperm parameters and testosterone level in rats. Andrologia, 50(7), Article e13044. https://doi.org/10.1111/and.13044.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Ademiluyi, A. O., Oyeniran, O. H., Jimoh, T. O., Oboh, G., Boligon, A. A. (2019). Fluted pumpkin (Telfairia occidentalis) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents. Journal of Food Biochemistry, 43(11), Article e13037. https://doi.org/10.1111/jfbc.13037.</mixed-citation><mixed-citation xml:lang="en">Ademiluyi, A. O., Oyeniran, O. H., Jimoh, T. O., Oboh, G., Boligon, A. A. (2019). Fluted pumpkin (Telfairia occidentalis) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents. Journal of Food Biochemistry, 43(11), Article e13037. https://doi.org/10.1111/jfbc.13037.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Ekayoda, O., Kadiri, H. E., Apiamu, A., Okpoghono, J. (2025). Comparative analysis of amino acid, proximate and mineral compositions of Persea americana seeds and Telfairia occidentalis seeds formulated diet. Food and Humanity, 4, Article 100564. https://doi.org/10.1016/j.foohum.2025.100564.</mixed-citation><mixed-citation xml:lang="en">Ekayoda, O., Kadiri, H. E., Apiamu, A., Okpoghono, J. (2025). Comparative analysis of amino acid, proximate and mineral compositions of Persea americana seeds and Telfairia occidentalis seeds formulated diet. Food and Humanity, 4, Article 100564. https://doi.org/10.1016/j.foohum.2025.100564.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Ekayoda, O., Kadiri, H. E., Apiamu, A., Okpoghono, J. (2025). Evaluating the impact of Persea americana and Telfairia occidentalis seeds in the liver of anaemic rats. Food Chemistry Advances, 6, Article 100942. https://doi.org/10.1016/j.focha.2025.100942.</mixed-citation><mixed-citation xml:lang="en">Ekayoda, O., Kadiri, H. E., Apiamu, A., Okpoghono, J. (2025). Evaluating the impact of Persea americana and Telfairia occidentalis seeds in the liver of anaemic rats. Food Chemistry Advances, 6, Article 100942. https://doi.org/10.1016/j.focha.2025.100942.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Paternina-Ricardo, S., Del Castillo, M.D., Sánchez-Martin, V., Garcia-Espiñeira, M., Cervantes-Ceballos, L., Arroyo-Salgado, B. et al. (2025). Exploring the efficacy of the biological properties of Persea americana Mill seed: Useful studies and perspectives in functional foods. Journal of Agriculture and Food Research, 24, Article 102428. https://doi.org/10.1016/j.jafr.2025.102428.</mixed-citation><mixed-citation xml:lang="en">Paternina-Ricardo, S., Del Castillo, M.D., Sánchez-Martin, V., Garcia-Espiñeira, M., Cervantes-Ceballos, L., Arroyo-Salgado, B. et al. (2025). Exploring the efficacy of the biological properties of Persea americana Mill seed: Useful studies and perspectives in functional foods. Journal of Agriculture and Food Research, 24, Article 102428. https://doi.org/10.1016/j.jafr.2025.102428.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Nasri, C., Halabi, Y., Aghzaf, S., Nounah, I., Brunel, M., Oubihi, A. et al. (2022). Seven Persea americana varieties essential oils comparison: Chemical composition, toxicity, antibacterial, and antioxidant activities. Biocatalysis and Agricultural Biotechnology, 44, Article 102468. https://doi.org/10.1016/j.bcab.2022.102468</mixed-citation><mixed-citation xml:lang="en">Nasri, C., Halabi, Y., Aghzaf, S., Nounah, I., Brunel, M., Oubihi, A. et al. (2022). Seven Persea americana varieties essential oils comparison: Chemical composition, toxicity, antibacterial, and antioxidant activities. Biocatalysis and Agricultural Biotechnology, 44, Article 102468. https://doi.org/10.1016/j.bcab.2022.102468</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Gonçalves, D., Gouveia, C. S. S., Ferreira, M. J., Ganança, J. F. T., Pinto, D. C. G., De Carvalho, M. A. A. P. (2024). Comparative analysis of antioxidant and fatty acid composition in avocado (Persea americana Mill.) fruits: Exploring regional and commercial varieties. Food Chemistry, 442, Article 138403. https://doi.org/10.1016/j.foodchem.2024.138403.</mixed-citation><mixed-citation xml:lang="en">Gonçalves, D., Gouveia, C. S. S., Ferreira, M. J., Ganança, J. F. T., Pinto, D. C. G., De Carvalho, M. A. A. P. (2024). Comparative analysis of antioxidant and fatty acid composition in avocado (Persea americana Mill.) fruits: Exploring regional and commercial varieties. Food Chemistry, 442, Article 138403. https://doi.org/10.1016/j.foodchem.2024.138403.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Nascimento, A. P. S., Duarte, M. E. M., Rocha, A. P. T., Barros, A. N. (2025). Bioactive compounds, technological advances, and sustainable applications of avocado (Persea americana Mill.): A critical review. Foods, 14(15), Article 2746. https://doi.org/10.3390/foods14152746.</mixed-citation><mixed-citation xml:lang="en">Nascimento, A. P. S., Duarte, M. E. M., Rocha, A. P. T., Barros, A. N. (2025). Bioactive compounds, technological advances, and sustainable applications of avocado (Persea americana Mill.): A critical review. Foods, 14(15), Article 2746. https://doi.org/10.3390/foods14152746.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Nasri, C., Halabi, Y., Hajib, A., Choukri, H., Harhar, H., Lee, L.-H. et al. (2023). Proximate composition, lipid and elemental profiling of eight varieties of avocado (Persea americana). Scientific Reports, 13(1), Article 22767. https://doi.org/10.1038/s41598-023-50119-y.</mixed-citation><mixed-citation xml:lang="en">Nasri, C., Halabi, Y., Hajib, A., Choukri, H., Harhar, H., Lee, L.-H. et al. (2023). Proximate composition, lipid and elemental profiling of eight varieties of avocado (Persea americana). Scientific Reports, 13(1), Article 22767. https://doi.org/10.1038/s41598-023-50119-y.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">De Oliveira, C.S., Andrade, J.K.S., Rajan, M., Narain, N. (2022). Influence of the phytochemical profile on the peel, seed and pulp of Margarida, Breda and Geada varieties of avocado (Persea americana Mill.) associated with their antioxidant potential. Food Science and Technology, 42, Article e25822. https://doi.org/10.1590/fst.25822.</mixed-citation><mixed-citation xml:lang="en">De Oliveira, C.S., Andrade, J.K.S., Rajan, M., Narain, N. (2022). Influence of the phytochemical profile on the peel, seed and pulp of Margarida, Breda and Geada varieties of avocado (Persea americana Mill.) associated with their antioxidant potential. Food Science and Technology, 42, Article e25822. https://doi.org/10.1590/fst.25822.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Ford, N. A., Spagnuolo, P., Kraft, J., Bauer, E. (2023). Nutritional composition of Hass avocado pulp. Foods, 12(13), Article 2516. https://doi.org/10.3390/foods12132516.</mixed-citation><mixed-citation xml:lang="en">Ford, N. A., Spagnuolo, P., Kraft, J., Bauer, E. (2023). Nutritional composition of Hass avocado pulp. Foods, 12(13), Article 2516. https://doi.org/10.3390/foods12132516.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Olas, B. (2024). The pulp, peel, seed, and food products of Persea americana as sources of bioactive phytochemicals with cardioprotective properties: A review. International Journal of Molecular Sciences, 25(24), Article 13622. https://doi.org/10.3390/ijms252413622.</mixed-citation><mixed-citation xml:lang="en">Olas, B. (2024). The pulp, peel, seed, and food products of Persea americana as sources of bioactive phytochemicals with cardioprotective properties: A review. International Journal of Molecular Sciences, 25(24), Article 13622. https://doi.org/10.3390/ijms252413622.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Aworunse, O. S., Popoola, J. O., Fayeun, L. S., Ahuekwe, E. F., Obembe, O. O. (2023). Morphological trait variation and correlation analysis in landraces of southern nigerian fluted pumpkin (Telfairia occidentalis Hook. F.). Chapter in a book: Biotechnological Approaches to Sustainable Development Goals. Springer, Cham, 2023. https://doi.org/10.1007/978-3-031-33370-5_5.</mixed-citation><mixed-citation xml:lang="en">Aworunse, O. S., Popoola, J. O., Fayeun, L. S., Ahuekwe, E. F., Obembe, O. O. (2023). Morphological trait variation and correlation analysis in landraces of southern nigerian fluted pumpkin (Telfairia occidentalis Hook. F.). Chapter in a book: Biotechnological Approaches to Sustainable Development Goals. Springer, Cham, 2023. https://doi.org/10.1007/978-3-031-33370-5_5.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Kayode, A. A. A., Kayode, O. T. (2011). Some medicinal values of Telfairia occidentalis: A review. American Journal of Biochemistry and Molecular Biology, 1(1), 30–38. https://doi.org/10.3923/ajbmb.2011.30.38.</mixed-citation><mixed-citation xml:lang="en">Kayode, A. A. A., Kayode, O. T. (2011). Some medicinal values of Telfairia occidentalis: A review. American Journal of Biochemistry and Molecular Biology, 1(1), 30–38. https://doi.org/10.3923/ajbmb.2011.30.38.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Ezenwata, I. S., Onyemeka, R. M., Makinde, S. C. O., Anyaegbu, C. F., Ogbuoka, R. C., Oyetunji, O. S. (2019). Analysis of variation among genotypes of fluted pumpkin (Telfairia occidentalis hook. f) using factor analysis and principal component analysis (PCA). International Journal of Engineering Applied Sciences and Technology, 4(7), 211–216. https://doi.org/10.33564/ijeast.2019.v04i07.035.</mixed-citation><mixed-citation xml:lang="en">Ezenwata, I. S., Onyemeka, R. M., Makinde, S. C. O., Anyaegbu, C. F., Ogbuoka, R. C., Oyetunji, O. S. (2019). Analysis of variation among genotypes of fluted pumpkin (Telfairia occidentalis hook. f) using factor analysis and principal component analysis (PCA). International Journal of Engineering Applied Sciences and Technology, 4(7), 211–216. https://doi.org/10.33564/ijeast.2019.v04i07.035.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Okon, U.I., Silver, E.O., Emeka, N.G. (2022). Genetic variability in proximate, mineral, vitamin, carotene and anti-nutrients content of fluted pumpkin (Telfairia Occidentalis Hook F). International Journal of Trend in Scientific Research and Development, 6(6), 962–970.</mixed-citation><mixed-citation xml:lang="en">Okon, U.I., Silver, E.O., Emeka, N.G. (2022). Genetic variability in proximate, mineral, vitamin, carotene and anti-nutrients content of fluted pumpkin (Telfairia Occidentalis Hook F). International Journal of Trend in Scientific Research and Development, 6(6), 962–970.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Oyetunde, O., Benson, G. A. S., Oyetunde, A. K., Olalekan, O. J., Chukwu, C. U., Anari, K. O. (2023). Agromorphological and nutritional quality profiles of fluted pumpkin (Telfairia occidentalis Hook F.) as influenced by cultivar, growing medium and soil amendment source. International Journal of Horticultural Science. https://doi.org/10.31421/ijhs/29/2023/11020.</mixed-citation><mixed-citation xml:lang="en">Oyetunde, O., Benson, G. A. S., Oyetunde, A. K., Olalekan, O. J., Chukwu, C. U., Anari, K. O. (2023). Agromorphological and nutritional quality profiles of fluted pumpkin (Telfairia occidentalis Hook F.) as influenced by cultivar, growing medium and soil amendment source. International Journal of Horticultural Science. https://doi.org/10.31421/ijhs/29/2023/11020.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Akin-Idowu, P. E., Onuoha, V. W., Aderibigbe, O. R., Taiwo, S. O., Ikoro, J., Akinleye, C. O. et al. (November 12–16, 2023). Sex differences in phytochemical and nutritional compositions of fluted pumpkin (Telfairia occidentalis) leaves. Proceedings of 41st Annual Conference of Hortson. Ogbomoso, Oyo State, Nigeria, 2023.</mixed-citation><mixed-citation xml:lang="en">Akin-Idowu, P. E., Onuoha, V. W., Aderibigbe, O. R., Taiwo, S. O., Ikoro, J., Akinleye, C. O. et al. (November 12–16, 2023). Sex differences in phytochemical and nutritional compositions of fluted pumpkin (Telfairia occidentalis) leaves. Proceedings of 41st Annual Conference of Hortson. Ogbomoso, Oyo State, Nigeria, 2023.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Uchenna, U. E., Shori, A. B., Baba, A. S. (2017). Inclusion of avocado (Persea americana) seeds in the diet to improve carbohydrate and lipid metabolism in rats. Revista Argentina de Endocrinología y Metabolism, 54(3), 140–148. https://doi.org/10.1016/j.raem.2017.07.005.</mixed-citation><mixed-citation xml:lang="en">Uchenna, U. E., Shori, A. B., Baba, A. S. (2017). Inclusion of avocado (Persea americana) seeds in the diet to improve carbohydrate and lipid metabolism in rats. Revista Argentina de Endocrinología y Metabolism, 54(3), 140–148. https://doi.org/10.1016/j.raem.2017.07.005.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Tugiyanti, E., Iriyanti, N., Apriyanto, Y. S. (2019). The effect of avocado seed powder (Persea americana Mill.) on the liver and kidney functions and meat quality of culled female quail (Coturnix coturnix japonica). Veterinary World, 12(10), 1608–1615. https://doi.org/10.14202/vetworld.2019.1608-1615.</mixed-citation><mixed-citation xml:lang="en">Tugiyanti, E., Iriyanti, N., Apriyanto, Y. S. (2019). The effect of avocado seed powder (Persea americana Mill.) on the liver and kidney functions and meat quality of culled female quail (Coturnix coturnix japonica). Veterinary World, 12(10), 1608–1615. https://doi.org/10.14202/vetworld.2019.1608-1615.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Udoh, I.E., Onwuka, G.I., Ndife, J., Jim, M.S. (2024). Effect of fluted pumpkin (Telfairia occidentalis) seed flour supplementation on the nutritional and chemical properties of broken rice flour. African Journal of Agricultural Science and Food Research, 17(1), 1–14. https://doi.org/10.62154/ajasfr.2024.017.010439.</mixed-citation><mixed-citation xml:lang="en">Udoh, I.E., Onwuka, G.I., Ndife, J., Jim, M.S. (2024). Effect of fluted pumpkin (Telfairia occidentalis) seed flour supplementation on the nutritional and chemical properties of broken rice flour. African Journal of Agricultural Science and Food Research, 17(1), 1–14. https://doi.org/10.62154/ajasfr.2024.017.010439.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Vignesh, A., Amal, T. C., Sarvalingam, A., Vasanth, K. (2024). A review on the influence of nutraceuticals and functional foods on health. Food Chemistry Advances, 5, Article 100749. https://doi.org/10.1016/j.focha.2024.100749.</mixed-citation><mixed-citation xml:lang="en">Vignesh, A., Amal, T. C., Sarvalingam, A., Vasanth, K. (2024). A review on the influence of nutraceuticals and functional foods on health. Food Chemistry Advances, 5, Article 100749. https://doi.org/10.1016/j.focha.2024.100749.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Nyakang’i, C.O., Marete, E., Ebere, R., Arimi, J. M. (2023). Physicochemical properties of avocado seed extract model beverages and baked products incorporated with avocado seed powder. International Journal of Food Science, 2023, Article 6860806. https://doi.org/10.1155/2023/6860806.</mixed-citation><mixed-citation xml:lang="en">Nyakang’i, C.O., Marete, E., Ebere, R., Arimi, J. M. (2023). Physicochemical properties of avocado seed extract model beverages and baked products incorporated with avocado seed powder. International Journal of Food Science, 2023, Article 6860806. https://doi.org/10.1155/2023/6860806.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Kamle, M., Mahato, D. K., Sharma, B., Gupta, A., Shah, A. K., Mahmud, M. M. C. et al. (2024). Nutraceutical potential, phytochemistry of hemp seed (Cannabis sativa L.) and its application in food and feed: A review. Food Chemistry Advances, 4, Article 100671. https://doi.org/10.1016/j.focha.2024.100671.</mixed-citation><mixed-citation xml:lang="en">Kamle, M., Mahato, D. K., Sharma, B., Gupta, A., Shah, A. K., Mahmud, M. M. C. et al. (2024). Nutraceutical potential, phytochemistry of hemp seed (Cannabis sativa L.) and its application in food and feed: A review. Food Chemistry Advances, 4, Article 100671. https://doi.org/10.1016/j.focha.2024.100671.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
