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foodsyst

Food systems

Пищевые системы

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Федеральный научный центр пищевых систем им. В.М. Горбатова РАН

10.21323/2618-9771-2026-9-1-62-77

foodsyst-1001

Research Article

Статьи

Myricetin as a therapeutic agent: Molecular researches and clinical potentia

Мирицетин как терапевтическое средство: молекулярные исследования и потенциал клинического применения

https://orcid.org/0000-0003-3068-8718

Пратама

Б. П.

Pratama

B. P.

Бима П. Пратама, PhD в области послеуборочных технологий, научный сотрудник

Джалан Рая Серпонг, Южный Тангеранг, Бантен, Западная Ява, 15310

Bima P. Pratama, PhD in Post-harvest Technology, Researcher

Jl. Raya Serpong, South Tangerang, Banten, West Java, 15310

bimaputra.pratama@gmail.com

https://orcid.org/0000-0001-9421-9342

Хайрулла

А. Р.

Khairullah

A. R.

Асвин Р. Хайрулла, PhD в области ветеринарных наук, научный сотрудник

16911, Индонезия, Западная Ява, Богор, Джалан Рая Богор 46 км

Aswin R. Khairullah, PhD in Veterinary Science, Researcher

Jl. Raya Bogor Km. 46 Cibinong, Bogor, West Java, 16911

aswinrafif@gmail.com

https://orcid.org/0000-0001-9641-8222

Маруф

И. Ф.

Ma’ruf

I. F.

Ильма Фаузия Маруф, PhD в области химических наук, научный сотрудник

16911, Индонезия, Западная Ява, Богор, Джалан Рая Богор 46 км

Ilma F. Ma’ruf, PhD in Chemistry, Researcher

Jl. Raya Bogor Km. 46 Cibinong, Bogor, West Java, 16911

Ilma005@brin.go.id

https://orcid.org/0000-0002-6159-0652

Курниасих

Д. А.А.

Kurniasih

D. A. A.

Деа А. А. Курниасих, PhD, научный сотрудник

16911, Индонезия, Западная Ява, Богор, Джалан Рая Богор 46 км

Dea A. A. Kurniasih, PhD, Researcher

Jl. Raya Bogor Km. 46 Cibinong, Bogor, West Java, 16911

deaariani@gmail.com

Сукманади

М.

Sukmanadi

Мохаммад Сукманади, PhD, доцент

60115, Индонезия, Восточная Ява, Сурабая, округ Мулиорехо, Джалан Эйрлангга, кампус С

Mohammad Sukmanadi, PhD, Assistant Professor

Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115

moh-s@fkh.unair.ac.id

https://orcid.org/0000-0003-4543-1659

Мустофа

И.

Mustofa

Имам Мустофа, PhD в области ветеринарной репродукции, профессор

60115, Индонезия, Восточная Ява, Сурабая, округ Мулиорехо, Джалан Эйрлангга, кампус С

Imam Mustofa, PhD in Veterinary Reproduction, Professor

Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115

imam.mustofa@fkh.unair.ac.id

https://orcid.org/0000-0002-6013-0902

Акинтунде

А. О.

Akintunde

A. O.

Adeyinka O. Akintunde, PhD, доцент

Илишан-Ремо 121103, штат Огун

Adeyinka O. Akintunde, PhD, Assistant Professor

Ilishan-Remo 121103, Ogun State

adeyinka.akintunde@gmail.com

https://orcid.org/0000-0002-2067-717X

Ахмад

Р. З.

Ahmad

R. Z.

Риза З. Ахмад, PhD, научный сотрудник

16911, Индонезия, Западная Ява, Богор, Джалан Рая Богор 46 км

Riza Z. Ahmad, PhD, Researcher

Jl. Raya Bogor Km. 46 Cibinong, Bogor, West Java, 16911

riza011@brin.go.id

https://orcid.org/0000-0001-7939-9402

Пробинграт

А.

Proboningrat

Аннис Пробонинграт, PhD, доцент

60115, Индонезия, Восточная Ява, Сурабая, округ Мулиорехо, Джалан Эйрлангга, кампус С

Annise Proboningrat, PhD, Assistant Professor

Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115

annise.drh@gmail.com

https://orcid.org/0000-0001-7376-6187

Вардхани

Б. В.К.

Wardhani

B. W. K.

Бантари В. К. Вардхани, PhD, научный сотрудник

16911, Индонезия, Западная Ява, Богор, Джалан Рая Богор 46 км

Bantari W. K. Wardhani, PhD, Researcher

Jl. Raya Bogor Km. 46 Cibinong, Bogor, West Java, 16911

bantariwisynu@gmail.com

https://orcid.org/0009-0004-5867-4646

Юри

А. Дж.Б.

Yuri

A. J. B.

Анхель Дж. Б. Юрий, доктор медицинских наук, практикующий ветеринарный врач

60115, Индонезия, Восточная Ява, Сурабая, округ Мулиорехо, Джалан Эйрлангга, кампус С

Angel J. B. Yuri, Doctor of Medicine, Veterinary Practitioner

Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115

angeljbyuri@gmail.com

https://orcid.org/0000-0002-0700-7198

Лелиана

Л.

Leliana

Лулум Лелиана, PhD, доцент

Джокаркарта, 55281

Lulum Leliana, PhD, Assistant Professor

Yogyakarta, 55281

lulum.leliana@ugm.ac.id

https://orcid.org/0000-0002-1279-3904

Анзори

А. Н.М.

Ansori

A. N.M.

Ариф Нур Мухаммад Ансори, PhD в области ветеринарных наук, научный сотрудник;

кампус B Дхармавангса, Сурабая, Восточная Ява, 60286

Уттаракханд, 248007, Индия

Сурабая, Восточная Ява, 60493

Arif N. M. Ansori, PhD in Veterinary Science, Researcher

Kampus B Dharmawangsa, Surabaya, East Java, 60286

Uttarakhand, 248007, India

Surabaya, East Java, 60493

ansori.anm@gmail.com

https://orcid.org/0009-0003-1401-9749

Утомо

Д. Л.Х.

Utomo

D. L. H.

Дези Л. Х. Утомо, доктор медицинских наук, практикующий ветеринарный врач

60115, Индонезия, Восточная Ява, Сурабая, округ Мулиорехо, Джалан Эйрлангга, кампус С

Desi L. H. Utomo, Doctor of Medicine, Veterinary Practitioner

Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115

Desilailatul361@gmail.com

https://orcid.org/0009-0000-6600-9479

Никма

А. К.

Nikmah

A. K.

Анггун К. Никмах, практикант, программа обучения аквакультуре, факультет рыболовства и морского хозяйств

60115, Индонезия, Восточная Ява, Сурабая, округ Мулиорехо, Джалан Эйрлангга, кампус С

Anggun K. Nikmah, Practitioner

Kampus C Mulyorejo, Jl. Dr. Ir. H. Soekarno, Surabaya, East Java, 60115

anggunkhoirun.ak@gmail.com

https://orcid.org/0009-0001-8138-8021

Юлианти

В.

Yulianti

Вита Юлианти, PhD, научный сотрудник, Исследовательский центр биотных систем

16911, Индонезия, Западная Ява, Богор, Джалан Рая Богор 46 км

Wita Yulianti, PhD, Researcher

Jl. Raya Bogor Km. 46 Cibinong, Bogor, West Java, 16911

witaunand@gmail.com

Научно-исследовательский центр технологических процессов, Национальное агентство исследований и инноваций (BRIN)ИндонезияResearch Center for Agroindustry, National Research and Innovation Agency (BRIN)Indonesia

Научно-исследовательский центр ветеринарных наук, Национальное агентство исследований и инноваций (BRIN)ИндонезияResearch Center for Veterinary Science, National Research and Innovation Agency (BRIN)Indonesia

Исследовательский центр фармацевтических ингредиентов и традиционной медицины, Национальное агентство исследований и инноваций (BRIN)ИндонезияResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN)Indonesia

Исследовательский центр общественного здравоохранения и питания, Национальное агентство исследований и инноваций (BRIN)ИндонезияResearch Center for Public Health and Nutrition, National Research and Innovation Agency (BRIN)Indonesia

Отдел фундаментальной ветеринарной медицины, факультет ветеринарной медицины, Университет ЭйрланггаИндонезияDivision of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas AirlanggaIndonesia

Отдел ветеринарной репродукции, факультет ветеринарной медицины, Университет ЭйрланггаИндонезияDivision of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas AirlanggaIndonesia

Кафедра сельского хозяйства и промышленных технологий, Университет БэбкокаНигерияDepartment of Agriculture and Industrial Technology, Babcock UniversityNigeria

Отделение ветеринарной патологии, факультет ветеринарной медицины, Университет ЭйрланггаИндонезияDivision of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas AirlanggaIndonesia

Профессиональная программа ветеринарной медицины, факультет ветеринарной медицины, Университет ЭйрланггаИндонезияProfession Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas AirlanggaIndonesia

Кафедра технологии пищевых продуктов и сельскохозяйственной продукции, факультет сельскохозяйственных технологий, Университет Гаджа МадаИндонезияDepartment of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Gadjah MadaIndonesia

Департамент аспирантуры, Университет Эйрлангга; Институт фармацевтических наук Уттаранчала, Университет Уттаранчала; Исследовательская группа медицинской биотехнологии, Виртуальный исследовательский центр биоинформатики и биотехнологииИндонезияPostgraduate School, Universitas Airlangga; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University; Medical Biotechnology Research Group, Virtual Research Center for Bioinformatics and BiotechnologyIndonesia

Программа обучения аквакультуре, факультет рыболовства и морского хозяйства, Университет ЭйрланггаИндонезияAquaculture Study Program, Faculty of Fisheries and Marine, Universitas AirlanggaIndonesia

Исследовательский центр биотных систем, Национальное агентство исследований и инноваций (BRIN)ИндонезияResearch Center for Biota Systems, National Research and Innovation Agency (BRIN)Indonesia

2026

17042026

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Copyright © Pratama B.P., Khairullah A.R., Ma’ruf I.F., Kurniasih D.A., Sukmanadi M., Mustofa I., Akintunde A.O., Ahmad R.Z., Proboningrat A., Wardhani B.W., Yuri A.J., Leliana L., Ansori A.N., Utomo D.L., Nikmah A.K., Yulianti W., 2026

2026

Пратама Б.П., Хайрулла А.Р., Маруф И.Ф., Курниасих Д.А., Сукманади М., Мустофа И., Акинтунде А.О., Ахмад Р.З., Пробинграт А., Вардхани Б.В., Юри А.Д., Лелиана Л., Анзори А.Н., Утомо Д.Л., Никма А.К., Юлианти В.

Pratama B.P., Khairullah A.R., Ma’ruf I.F., Kurniasih D.A., Sukmanadi M., Mustofa I., Akintunde A.O., Ahmad R.Z., Proboningrat A., Wardhani B.W., Yuri A.J., Leliana L., Ansori A.N., Utomo D.L., Nikmah A.K., Yulianti W.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.fsjour.com/jour/article/view/1001

Myricetin is a polyphenolic flavonol that is commonly present in tea, grapes, fruits, vegetables, and a number of medicinal plants. It is known to have a number of biological actions that are important for human health. Myricetin stands out for its multifunctional potential in the prevention and treatment of different infectious and degenerative disorders, especially as interest in natural bioactive chemicals grows. The primary mechanism entails robust antioxidant action by scavenging reactive oxygen species (ROS) and inducing the endogenous enzymes like catalase and superoxide dismutase. Furthermore, myricetin has anti-inflammatory properties via inhibiting the activation of the MAPK (mitogen-activated protein kinase) and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathways, which lowers the synthesis of proinflammatory cytokines. Numerous in vitro and in vivo investigations have demonstrated its capacity to suppress the growth of cancer cells, trigger apoptosis, and stop metastasis in the context of oncology. Myricetin decreases cholesterol, promotes endothelial function, and guards against atherosclerosis in the cardiovascular system. Its neuroprotective benefits are also encouraging, especially in terms of protecting dopamine in Parkinson’s disease and preventing β-amyloid buildup in Alzheimer’s disease. Furthermore, myricetin is important for preventing diabetes and obesity because it regulates blood glucose, improves insulin sensitivity, and modifies lipid metabolism. Antimicrobial and antiviral activities have also been documented, although they are still limited to experimental studies. Nevertheless, two significant obstacles to its conversion to practical applications are the lack of extensive clinical trials and the limited oral bioavailability. Future studies will concentrate on developing novel formulations, investigating safe and efficient dosages, and conducting thorough clinical trials. All things considered, myricetin shows significant promise as a multipurpose natural therapeutic candidate that promotes human health.

Мирицетин — полифенольный флавонол, широко распространенный в чае, винограде, фруктах, овощах и ряде лекарственных растений. Известно, что он обладает рядом биологических свойств, важных для здоровья человека. Мирицетин выделяется своим многофункциональным потенциалом в профилактике и лечении различных инфекционных и дегенеративных заболеваний, особенно в связи с ростом интереса к природным биоактивным веществам. Основной механизм его действия заключается в мощном антиоксидантном действии, которое выражается в нейтрализации активных форм кислорода (АФК) и индукции таких эндогенных ферментов, как каталаза и супероксиддисмутаза. Кроме того, мирицетин обладает противовоспалительными свойствами, ингибируя активацию сигнальных путей MAPK и NF-κB, что снижает синтез провоспалительных цитокинов. Многочисленные исследования in vitro и in vivo продемонстрировали его способность подавлять рост раковых клеток, запускать апоптоз и останавливать метастазирование в онкологии. Мирицетин снижает уровень холестерина, способствует улучшению функции эндотелия и защищает сердечно-сосудистую систему от атеросклероза. Его нейропротекторные свойства также весьма обещающие, особенно в плане защиты дофамина при болезни Паркинсона и предотвращения накопления β-амилоида при болезни Альцгеймера. Кроме того, мирицетин важен для профилактики диабета и ожирения, поскольку он регулирует уровень глюкозы в крови, улучшает чувствительность к инсулину и меняет липидный обмен. Также были зарегистрированы его антимикробные и противовирусные свойства, хотя они пока ограничены экспериментальными исследованиями. Тем не менее, двумя существенными препятствиями для практического применения являются отсутствие обширных клинических испытаний и ограниченная биодоступность при пероральном приёме. Будущие исследования будут сосредоточены на разработке новых формул, изучении безопасных и эффективных дозировок и проведении тщательных клинических испытаний. Учитывая всё это, мирицетин имеет возможность стать многоцелевым природным терапевтическим веществом, улучшающим здоровье человека.

Мирицетинфлавоноидрастениелекарствоздоровье человека

Myricetinflavonoidplantmedicinehuman health

Данная работа была поддержана Национальным агентством исследований и инноваций (BRIN) и Индонезийским фондом развития образования (LPDP) в рамках программы RIIM — Конкурсная волна 7 (Указ № 61/II.7/HK/2024). Финансирующая организация не принимала участия в разработке исследования, сборе, анализе или интерпретации данных, а также в написании данной статьи. БЛАГОДАРНОСТИ: Авторы выражают искреннюю благодарность Национальному агентству исследований и инноваций (BRIN) и Индонезийскому фонду развития образования (LPDP) за финансовую поддержку в рамках Программы исследований и инноваций для передовой Индонезии (RIIM) — Конкурсная волна 7, предусмотренной Постановлением заместителя по научным исследованиям и содействию инновациям BRIN № 61/II.7/HK/2024. Авторы также выражают благодарность Научно-исследовательской организации сельского хозяйства и продовольствия (ORPP BRIN) за материальную и нематериальную поддержку, и Научно-исследовательскому центру минеральных технологий, BRIN за ценную помощь в подготовке и выполнении данной авторской работы. Мы выражаем благодарность Институту технологий Суматры (ITERA) за совместную работу.

This work was supported by the National Research and Innovation Agency (BRIN) and the Indonesia Endowment Fund for Education (LPDP) through the RIIM Program — Competitive Wave 7 (Decree No. 61/II.7/HK/2024). The funding body had no role in the design of the study, the collection, analysis or interpretation of data, or in writing of the manuscript. ACKNOWLEDGEMENTS: The authors would like to express their sincere gratitude to the National Research and Innovation Agency (BRIN) and the Indonesia Endowment Fund for Education (LPDP) for financial support through the Research and Innovation for Advanced Indonesia (RIIM) Program — Competitive Wave 7, as stipulated in the Decree of the Deputy for Research and Innovation Facilitation of BRIN No. 61/II.7/HK/2024. The authors also acknowledge material and immaterial support from the Research Organization for Agriculture and Food (ORPP BRIN) and the valuable assistance of the Research Center for Mineral Technology, BRIN, in the preparation and completion of this manuscript. Collaborative contributions from Institut Teknologi Sumatera (ITERA) are gratefully appreciated.

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The authors declare that there are no conflicts of interest present.